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The article presents a review of the literature on the role of oxidative stress in the development of metabolic and cardiovascular disorders in children and adolescents against the background of obesity. It has been shown that oxidative stress should be considered as an early marker of metabolic syndrome. Prescribing drugs with antioxidant activity in the complex treatment of obese children with confirmation of oxidative stress is effective. The article also presents the experience of the authors of the effective use of metabolic therapy in obese children.

Obesity is one of the high-priority problems in modern pediatrics. To study early cardiovascular risks in adolescent children with obesity, 85 subjects with exogenous constitutional obesity at the age of 12–18 years were examined. The patients were divided into two groups: the first group, 41 patients with uncomplicated primary exogenous constitutional obesity, the second — 44 patients with obesity and metabolic syndrome; controls included 20 healthy adolescents of the same age with normal body weight. Based on a comprehensive study of the structural and functional state of the myocardium and intracardiac hemodynamics, it was found that the early significant criteria for cardiovascular risk in obese adolescent children were insulin resistance (HOMA-IR over 3.4), labile arterial hypertension, impaired relaxation, and/or concentric LV remodeling.

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