No abstract

No abstract

The authors of the article describe the dependence of the effectiveness of any drug on the "correctness" of its choice for the patient and conclude that patient profiling can serve as an effective clinical method for selecting optimal therapy. When prescribing antihistamines, it is suggested to use the following main patient profiles: children, working adults, elderly patients. Each profile has its own specific purpose. The article presents own clinical experience of using fexofenadine based on patient profiling. Cases of fexofenadine therapy in patients with allergic rhinitis and chronic urticaria are given as specific examples. Fexofenadine has an optimal safety profile with minimal impact on concentration and cognitive abilities. In this regard, it can be recommended to employees whose activities are associated with the speed of psychomotor reactions, schoolchildren and university students, elderly patients with high drug load and comorbidity.

Quifenadine , a drug developed in the laboratory of M.D.Mashkovsky in the 1970s, is one of the first examples of the creation of a new class of nonsedative antihistamines of multifunctional action, combining high selective activity to block type 1 histamine receptors, the ability to block the action of serotonin and enhance histaminase activity in tissues. The article describes the latest data on the study of the pharmacokinetics of the drug, presents studies on the efficacy and safety of quifenadine. Currently, the question remains open to which generation of antihistamines to include quinuclidine, considering all the described characteristics.