The neuropeptide C-type natriuretic peptide (CNP) is the primary biologically active natriuretic peptide in brain. Using in situ hybridization, the present report demonstrates that CNP regulates egr-1, c-fos and junB immediate early gene expression in rat brain. In the frontal cortex, CNP induced immediate early gene expression whereas it inhibited dose-dependently the cocaine-induced early gene expression in the dopaminergic projection fields nucleus accumbens and caudate-putamen. CNP may produce its effect directly on dopaminergic neurons because we found that its receptor, guanylyl cyclase GC-B, was expressed in the mesencephalon where dopaminergic neurons originate, as well as in their projection fields. The inhibition by CNP of the early gene expression elicited by cocaine in the caudate-putamen is correlated with a CNP-evoked decrease in cocaine-induced rise in extracellular dopamine, measured by in vivo microdialysis experiments. The significance of the inhibition of cocaine-induced dopamine release and early gene induction by the endogenous peptide CNP is demonstrated by data indicating that CNP reduced the cocaine-induced spontaneous locomotor activation. By inhibiting dopaminergic neuronal activity, CNP represents a potential negative regulator of related behavioural effects of cocaine.

Polyurethane foam (PUF) is actively used for thermal insulation. The main characteristic of thermal insulation is effective thermal conductivity. We studied the effective thermal conductivity of six samples of PUF with different types and sizes of cells. In the course of the research, heat was supplied to the foam using an induction heater in three different positions: above, below, or from the side of the foam. The studies were carried out in the temperature range from 30 to 100 °C. The research results showed that for all positions of the heater, the parameter that makes the greatest contribution to the change in thermal conductivity is the cell size. Two open-cell foam samples of different sizes (d = 3.1 mm and d = 0.725 mm) have thermal conductivity values of 0.0452 and 0.0287 W/m⸱K, respectively, at 50 °C. In the case of similar cell sizes for any position of the heater, the determining factor is the type of cells. Mixed-cell foam (d = 3.28 mm) at 50 °C has a thermal conductivity value of 0.0377 W/m⸱K, and open-cell foam (d = 3.1 mm) at the same temperature has a thermal conductivity value of 0.0452 W/m⸱K. The same foam sample shows different values of effective thermal conductivity when changing the position of the heater. When the heater is located from below the foam, for example, mixed-cell foam (d = 3.4 mm) has higher values of thermal conductivity (0.0446 W/m⸱K), than if the heater is located from above (0.0390 W/m⸱K). There are different values of the effective thermal conductivity in the upper and lower parts of the samples when the heater is located from the side of the foam. At 80 °C the difference is 40% for the open-cell foam (d = 3.1 mm).

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