In the process of ontogenesis, individual organs and systems mature gradually completing their development in different periods of life. This heterochrony of maturation determines the features of organism-functioning in children of different ages. However, the data in scientific literature do not reveal the features of the vegetative status of preschool children. Therefore, the goal of our work was to determine the level of vegetative homeostasis, which indicates the ratio of sympathetic (YANG) and parasympathetic (YIN) functional activity of the autonomic nervous system in preschool children. The methodology of functional-vegetative diagnostics (FVD) elaborated by Professor V. G. Makats (2016) allowed identifying acupunctural channels and discovered a previously unknown human functional-vegetative system. The diagnostic complex “BIOTEST-12M” (Diagnostic complexes VITA-01-M and computerized system VITA-01-Biotest) serves as the technical tool of the FVD. The specific dynamics of increasing systemic-functional stabilization indicates the formation of age-related mechanisms of functional-vegetative homeostasis and the peculiarities of physiological development of preschool children. We found 28.5% of the surveyed preschool children in the zone of vegetative equilibrium, and 50% have parasympathicotonia. The sympathetic orientation of the levels of vegetative equilibrium by the years of life of preschool children in the female group (FG) is identical and indicates the multi-directional activity of individual systemic complexes.

Results of a study of lipid peroxidation, antioxidant system components, and cholinergic neurotransmitter system in the organs of experimental rats of different ages exposed to alimentary synthetic estrogen are presented. Given the state of peroxidation processes and AChE activities in female rats exposed to xenoestrogen, it is possible to assume the possibility of the restructuring of the functioning of mediator and enzyme systems and additional strengthening of pathological symptoms. In the future, such phenomena may trigger the reduction of potential of compensatory mechanisms in compromising the health of the consumers. In puberty, females were more sensitive to nutritional synthetic estrogen than mature animals, thus proving that age is another factor in xenoestrogen exposure. Because of the changes in the rates of reactions to detoxification but not to the metabolism of estrogen received into the organism, particularly with food, with age the animals were less susceptible to the effects of these substances.

The paper provides a simulation of the occurrence of <em>Ambrosia</em> pollen in Ukraine both in terms of a determination of the regions with high pollen concentrations and the time when the high pollen load occurs. Simulation was performed using the SILAM system and the following pollen mapping using the Grid Analysis and Display System. Simulation results were compared with the aerobiological data available from six monitoring stations in Ukraine. A decrease in the concentrations of <em>Ambrosia</em> pollen, the duration of the <em>Ambrosia</em> season, and patient exposure to the <em>Ambrosia</em> pollen were apparent from SE to NW of Ukraine. A close correlation between the modeled and actually registered pollen concentration values and ragweed pollen release periods was observed in all the cities for which the <em>Ambrosia</em> pollen monitoring data had been collected. Further investigations are required to provide accurate forecasts for other types of airborne allergens.

<p>The control of plant pollen season patterns is especially important in the expectation of climate change, as the timing of potential varying pollen seasons affects the human population. An ever-increasing number of people suffer from hay fever symptoms with varying severity during the pollen season. This paper presents data on the seasonal variations of pollen concentration and the factors which are the likely causes of these variations in Vinnytsya, a city in Central Ukraine, in order to establish the apparent pattern of this variation and so improve the efficiency of hay fever control in Ukraine.</p><p>Pollen counts were obtained by gravimetric and volumetric methods employing a Hirst-type volumetric spore trap.</p><p>Alder (<em>Alnus</em>) and birch (<em>Betula</em>) peaks of pollen release occurred approximately 1 month earlier than was observed at the end of the twentieth century. This was due to the seasonal heat accumulation related to the appropriate temperature regimen registered in January and February prior to the growing season. Other trees – including poplar (<em>Populus</em>), maple (<em>Acer</em>), walnut (<em>Juglans</em>), common hazel (<em>Corylus</em>) – did not show distinct changes in pollen season pattern over the past decades.</p><p>Mean daily temperature seems to be the leading factor promoting early season onset and a seasonal pollen peak shift of the grass and herb flora such as ragweed (<em>Ambrosia</em>). The shift of the ragweed seasonal pollen maximum towards later in the season correlated with higher temperatures during September. Our study has shown that droughts may also significantly decrease the ragweed pollen concentration.</p>

Background. Disorders of autonomic nervous system caused up to 80% of functional disorders. There is no information about the influence of magnetotherapy (MT) on the indicators of vegetative homeostasis, which disturbance is a cause of functional pathology.Objectives. The aim of the study is to investigate vegetative rehabilitation trend of MT in various initial conditions of functional-vegetative disorders.Methods. Functional-vegetative diagnostics method by V.G. Makats was chosen as a method of control of MT impact. The diagnostic complex BIOTEST-12M was a technical tool. 38 children of different age and gender treated in the Department of Physiotherapy of Vinnytsia Regional Children Clinical Hospital in 2016-2017 were involved in the research. The patients were divided into 7 groups according to the levels of functional vegetative homeostasis.Results. MT had a different effect on vegetative activity as well as systemic and functional dependence, according to the coefficient of functional vegetative homeostasis. The most positive effect was evidenced in a group with a significant parasympathicotonia (group 1). In the group with severe sympathicotonia (group 6) it had negative effect. There were no gender and age-related characteristic features of the influence of MT on the dispersion of vegetative levels.Conclusions. Rehabilitation expediency requires maintenance of functional vegetative homeostasis at the level of FcP-VB-FcS in conjunction with functional-vegetative diagnostics using the method of V.G. Makats. Magnetotherapy can be recommended to be used only for patients with significant and expressed parasym­pathicotonia.