Abstract. Aim — еvaluation of the adsorptive potential of carbon dressing, including its activity towards microbial cells of clinical strains with high antimicrobial resistance, and its effect on the course of wound process after removing a massive tumor in Guerin's rats. Materials and Methods. Microbial cell adsorption of S. aureus, A. baumannii and K. Pneumoniae cultures were studied in vitro. Woundplanimetry, photo-monitoring, and odor control on a verbal rating scale were carried out to control the state of wounds. Results: 1-hour contact of cell cultures with adsorptive carbon dressing ensured the decrease in the number of bacterial cells by 60.6-96.3%.Theuse of dressing after removing the tumor permitted to stop quickly capillary bleeding, stop/reduce traumatic edema, lower the risk of infectingthe wounds under recurrence of carcinoma growth and increase the average lifespan of animals by 1.5 times. Conclusion: adsorptive carbon dressing with high adsorption potential can be considered asa promising application means for the prevention and treatment of wound infection.