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Effects of different smoking methods on microbial load on freshly collected freshwater mud fish, Clarias gariepinus samples from Oyo State Fisheries Department, Ibadan in SouthWestern Nigeria was carried out. Seventy-two C. gariepinus (505 ± 0.45g and 25.5 ± 1.30cm) were collected and sorted into 4 groups. 10 fish samples from groups 1, 2 and 3 were subjected to cold smoking, hot smoking and oven drying methods respectively using group 4 as standard. Samples were tested for microbial loads in triplicate at the end of 24, 48 and 72 hrs. Some of the microbes identified were;