Aquaculture sector if fully exploited has great potential of boosting foreign exchange, household nutritional and income levels. However, not much has been done regarding economic analysis of aquaculture production to attract and guide investment. This study was carried out to assess the profitability and viability of the aquaculture enterprises in central Uganda. The study focused on the socioeconomic and production characteristics, profitability indices and significant challenges experienced by the fish farmers. The fish farmers were selected using simple random and purposive Original Research Article