Foot-and-mouth disease (FMD) was first documented in domestic stock in Botswana in the early 1930s and since then the country opted for eradication of FMD from all her livestock-rearing areas. A multipronged control strategy was adopted along the pathway towards eradication that initially included strategic apthisation of cloven-hooved domestic stock up to 1964, movement restriction through cordon fences and quarantine system from the 1950s, and vaccination using readily available commercial vaccines from the mid-1960s, to date. This has resulted in 78% of the country's land area being officially declared and recognized by the World Organisation for Animal Health (OIE) as FMD free without vaccination. However, the disease has remained endemic in the northern parts of the country, owing largely to co-existence of livestock and wildlife. We applied a qualitative risk analysis method in our study to assess the risk of FMD outbreak in zone 2 because of interaction between cattle and buffalo across a man-made physical barrier, southern buffalo fence, in the north of the country. The assessed risk was rated 'moderate' with moderate level of uncertainty, meaning assessment of mitigation options should be done before authorising import of cattle and cattle product from zone 2. Because of cost escalation associated with FMD controls, particularly zoning with cordon fences in the face of relentless trampling by elephants, we concluded that there is a need to revise the national goal of country-wide eradication of FMD in livestock rearing areas to a more achievable outcome for zone 2. We recommend adoption of husbandry management practices and marketing approaches that recognizes co-existence of cattle and wildlife in zone 2 as an exception to the rest of the country. Such an approach should be rooted not on geographic occurrence of FMD nor separation of the two species but on food product safety guarantees along the value chain, and we believe this to be critical for sustainability of FMD management and livelihoods in zone 2.