This study determined the therapeutic potentials of vitamin C, glutathione, and garlic on the hepatic and histological changes induced by uproot-pesticide on albino Wistar rats. All animal groups (except normal control) received intraperitoneally 50 mg/kg body weight of uproot-pesticide (a commercially formulated glyphosate-based herbicide) on alternate days and daily oral administration (except Uproot control) of 20 mg/ kg body weight of glutathione, vitamin C, and garlic as nutritional supplements singly and in combination for 28 days. Liver function and oxidative stress parameters of the liver were determined using blood and liver samples. Histological studies were done on the liver tissue. The values obtained showed significant variation of measured parameters in Uproot control compared to groups administered nutritional supplements and the control. These variations indicated oxidative liver damage and significant therapeutic potential of the nutritional supplements. Other observed significant and non-significant changes were discussed.