ObjectiveTo evaluate the difference in intravitreal bevacizumab (IVB) injection timing as adjuvant therapy to panretinal photocoagulation in patients with diabetic retinopathy combined with diabetic macular edema.MethodsThis was a retrospective nonrandomized study. Forty eyes with severe non-proliferative diabetic retinopathy (NPDR) or proliferative diabetic retinopathy (PDR) were divided into two groups; the IVB injection prior to, or after, panretinal photocoagulation. Changes in central macular thickness between the two groups were measured.ResultsThere was no significant difference in change in central macular thickness between two groups after treatment (p=0.66), neither in eyes with severe NPDR groups (p=0.48) nor eyes with PDR (p=0.82).ConclusionIVB injection after panretinal photocoagulation gives insignificant difference in changes in central macular thickness with injection prior to laser treatment in patients with diabetic retinopathy combined with diabetic macular edema.

Background and Objective: To evaluate the Inner-retinal cells survival after low duration laser treatment (50ms duration) measured by electroretinogram in patient with diabetic retinopathy Methods: Twenty-two eyes with severe nonproliferative diabetic retinopathy or proliferative diabetic retinopathy that underwent three panretinal photocoagulation treatments were prospectively followed. The patients were divided into two groups involving the standard laser or low-duration laser treatment. Survival of the inner retina was assessed using a full-field electroretinography involving changes in amplitude and implicit times of the b-wave rod response. Results: There was no significant change in amplitude in eyes treated with the low-duration laser (-14.29±30.479 µV; p=0.172), but there was a significant change in eyes treated with the standard laser (-45.65±28.189 µV; p=0.001). There was no significant change in implicit times in each group (p=0.177 and p=0.685, respectively). The change in amplitude in eyes treated with the low-duration laser was significantly lower than in eyes treated with the standard laser (-71.43±25.408 versus 8.18±86.432, respectively; p=0.018). Conclusions: Treatment with the low-duration laser is effective in maintaining the survival of inner retinal cells.