The objective of present study was to evaluate the anti-ulcer activity of hydro-alcoholic extract of Corchorus capsularis seeds. Mainly hyper secretion of gastric acid and pepsin causes ulcer in patients. Plant extracts and polyherbal formulations are two of the most appealing sources of new drug. This type of extract formulations are showing good results in the treatment of gastric ulcers. In this study anti-ulcer activity was investigated by pyloric ligation, aspirin and stress induced gastric ulcer in albino wistar rats. The extract was given at the dose of 250mg/kg (CCLD- Corchorus capsularis low dose) and 500mg/kg (CCHD- Corchorus capsularis high dose) in all the experimental models. Ranitidine (150mg/kg) was used as standard drug. CCLD and CCHD showed 37.49% and 63.14% ulcer inhibition respectively, whereas ranitidine 69.69% against pylorus ligation induced ulcer. In aspirin induced ulcer model the extract showed ulcer inhibition 48.64% and 64.00% in CCLD and CCHD respectively whereas the standard drug ranitidine exhibited 84.64% ulcer inhibition. In stress induced ulcer model CCLD, CCHD and ranitidine exhibited 48.64%, 64.00% and 84.64% ulcer inhibition respectively. In all the models ethanolic extract of Corchorus capsularis seeds has shown significant anti-ulcer activity in dose dependent manner.

The novel coronavirus disease, first identified in 2019 known as COVID-19, is caused by a new strain of severe acute respiratory syndrome coronavirus (SARS-CoV or SARS-CoV-1), named SARS-CoV-2. Recent studies showed that the virus may be airborne and spreads through small respiratory droplets of saliva in aerosols, indirect or direct physical contact with the affected individual, in a similar way to the cold and influenza. Emerging studies also demonstrate the importance of the throat along with salivary glands as sites of viral replication and transmission in early COVID-19 infection. The most common route of entry of SARS-CoV-2 is the upper respiratory tract (nasopharynx) that slowly reaches the lower respiratory tract to infect the epithelial cells within the lungs which can cause lung damage and severe respiratory symptoms, if not treated immediately. Averting colonization of the virus in the nasopharynx could be one of the best options to reduce the incidence of severe infection. It has been well-documented that iodine is one of the most effective of all antimicrobials available. Hospitals and medical facilities worldwide use povidone-iodine (PVP-I) as a standard of care in infection control. Several research studies during the ongoing COVID-19 pandemic showed the in vitro and in vivo efficacy of iodine-containing solutions such as PVP-I (Betadine), Iodine-V (Essential Iodine Drops) etc. and other iodine complexes to effectively kill the SARS-CoV-2 virus within few seconds to hours. Few commercially available iodine-containing gargling, mouthwash, and nasal spray solutions have been recommended to use in humans against SARS-CoV-2 infection by experts to prevent viral spread, especially among health workers. The present article aims to summarize these studies and highlights the rationale, safety and recommendations of use of iodine as an effective method to decrease the viral load during the early COVID-19 infection.