What is already known about this topic? Data suggest that more men than women are dying of coronavirus disease 2019 (COVID-19) worldwide, but it is unclear why. What is added by this report? We describe an approach that considers biological and psychosocial factors that affect men's health and how these factors may intersect. Clinical, public health, community, and policy examples illustrate what can be done, and is being done, to address men's COVID-19-associated mortality risk. Our approach highlights the importance of examining COVID-19-associated mortality risk from a men's health perspective rather than one that focuses solely on sex differences. What are the implications for public health practice? We can seize this moment to reimagine and redesign our health care and public health systems to consider the many factors that influence men's health.

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