The amine material is part of the functional group of carbon compounds studied in the even semester in the class of 3rd grade High School. This material is closely related to everyday life, especially the structures, nomenclature, physical properties, chemical properties, synthesis, uses and spectra inframerah (IR). Natural and synthetic amines play a role in human physiological and biological activities, including hormones, amino acids, nicotine, anti-irritant shampoos, engine lubricants, and drugs classified as Narcotics, Psychotropics and Additives (Napza). Students can be given a problem in the learning process related to reality. One of the learning models that can be used in discussing amine material is the Problem Based Learning (PBL) learning model because amines are close to life. This research aim is to develop LKPD and determine the validity test. The type of research is R&D (Research and Development) with a 4-D model, namely define, design, develop and disseminate, which is limited to create on validity tests using research instruments in the form of questionnaires. The research was conducted by testing the validity of the resulting LKPD. The research data by five expert validators were analyzed through the Aiken's V formula scale. Based on the analysis of the actual validity of test questionnaires, Problem Based Learning-based worksheets have been produced, especially on the excellent amine material (0.87).