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This work presents analysis of modern scientific literature on determination of the function of tonsils of Waldeyer's ring (pharyngeal lymphoid tissue ring) and their role in the establishment and functioning of the local and humoral immunity in human organism. Tonsils are the «first line of defense» courtesy of the factors on nonspecific protection of the mucous membranes of upper air passages. Characteristic are for these factors: diverse action mechanisms; they have typically antifungal, antibacterial action, which was noted in the factors of the system of non-specific secretory lipoprotease inhibitors, elafins and lactoferrins.Differential immunodiagnostics between some pathological conditions of these structures can be carried out by way of determination of modern noninvasive methods of study of the immune factors, such as determination of cytokines, protective proteins, allergy, oropharyngeal secretion, reaginic antibodies; as well as for the assessment of provided treatment efficacy.Bearing in mind the obtained data of the analysis of literature sources it can be said, that even under the conditions of a chronic inflammation the Waldeyer's ring tonsils have a marked immunological effect owing to cytokines, cells-regulators and effector cell. Because even under such conditions they can produce polypeptides that have the regulatory and antitumoral capacity. The results of the studied literature sources indicate of the posed problem. Thus, as the active components of the local and systemic immunity the Waldeyer's ring tonsils must be maximally preserved except cases when they serve as the permanent source of infection with irreversible changes and negative effect on the associated organs.

The aim: The aim of our study was to determine effect of whole body vibration on the bone tissue remodeling, determine the correlation between bone mineral density, markers of bone metabolism and level of vibration stimulus. Materials and methods: Four experimental groups Wistar rats were exposed to vertical whole body vibration during 28 days. Blood intake and QCT-scanning of the lumbar spine was performed on the 28th and 56th day of study. Results: The largest loss of trabecular bone was observed in experimental groups III (0.51g) and IV (1.15g), which was decreasing to 12% (p<0.05) and 14% (p<0.05), respectively, in comparison with the control group. After 56th day of the experiment, bone loss dynamics was the following: in the 1st group ≤ 10% (p <0.05), in the 2nd ≤ 12% (p <0.05), in the 3rd ≤ 17 % (p <0.05), and 4th ≤ 22% (p <0.05) compared with the control group. Changes in the level of hydroxyproline in the first experimental group were not statistically significant (p>0.05), in the second group – increased by 19.3% compared with the control rates, in the third – by 65.3%, and in the fourth – the level doubled (p<0.05). Increase of free hydroxyproline indicates violations in the balance between destruction and compensatory acceleration of collagen biosynthesis, which gradually decreases up to the 56th day. It has been determined that with the increase in vibration frequency, elevation of osteocalcin level in rats’ blood is observed. Conclusions: Acceleration 0.51g increases the rate of bone metabolism, causes collagen metabolism disorders, loss of bone mineral mass, which further leads to osteoporosis.