A compact fiber-optic point-measuring fluorosensor fully adapted to clinical studies is described. The system can use two excitation wavelengths, 337 and 405nm, obtained from a nitrogen laser directly, or after dye laser conversion, respectively. The image intensifier used in the spectrometer can be gated with a variable time delay, allowing also time-resolved spectra to be extracted, with a time resolution of about 4ns. Moreover, diffusely scattered white light can be spectrally recorded. The system is fully computer controlled enabling short recording times in clinical application, which are illustrated.

CTuK23 O p t i c a l properties of breast lumours detcrmincd by B laser-pulse mammograplt 11. Wabnilz', U. Crosenick', H. Rinncherg', K. 'Th. Mmvta', P. Sfhlag' ' r h y~i k~l , s~h~T~~h " i~h~ nundcsanstalt, Abbesrr. 2-12. D-In587 Berlin, Gemmy RobErt-Rocsnle-Klinik, CharitC, llumhaldt-Uniucrsitit, Lndmhergcr Wcg 80. IL1112S Herlin,Grmany Time-domain optical mammography allnw~ U) derive optical propenie3 of tumwn and n~nnill breast tissue robustly fmm measured distributions of times o f flight. Prom ahsinpiion coeficienls determined at seveml selected wavelengths. total hacmoglohin conccdration and blood oxygen saturation can bc obtained.