The paper presents the synthesis of 5-substituted pyrimidine sulphonamides as well as the results of studies on the antibacterial and antifungal activity of obtained derivatives.

Fused pyrimidine derivativesFused pyrimidine derivatives R 0515Synthesis and Antibacterial Properties of Pyrimidopyrimidines. -Fourteen new pyrimidopyrimidines are prepared and microbially tested on 10 bacterial strains. Derivatives exhibit particular significant antibacterial effects if the phenyl ring contains a highly electronegative substituent. In these cases, the activity is comparable with sulfacarbamide and some of them have even stronger bacterial growth inhibitors than presently used antibiotics erythromycin. -(CIEPLIK*, J.; PLUTA, J.; GUBRYNOWICZ, O.; Sci. Pharm. 70 (2002) 3, 245-252; Dep. Org. Chem., Med. Acad., PL-50-137 Wroclaw, Pol.; Eng.) -Bartels 04-153

Our earlier works on synthesis and biological properties of the pyrimidine ring indicated that this system is extremely biologically active [...]

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