The article discusses the features and main approaches of Turkish foreign policy in the Middle East. Particular attention is paid to the history of the development of Turkish-American relations. The causes of the contradictions between Turkey and the United States on the security issues of the Middle East region are analyzed. At the same time, the commonality of the approaches of both countries in countering radical terrorism in the territories adjacent to Turkey is noted. The article also discusses the priority areas of Turkish foreign policy, new approaches and technologies in the first decade of the XXI century.