The aim: To determine changes of FSG of neutrophilic granulocytes of peripheral blood (NGPB) of patients with CHC with concomitant DM-2. Materials and methods: We’ve examined 180 patients with CHC: 160 with concomitant diabetes mellitus and 20 ones without it. The NGPB genome was studied using cytogenetic method. There were analyzed 100 interphase NGPB nuclei in the preparation, structural characteristics were evaluated according to indices: chromatization (IC), nucleolar (IN), pathologically altered nuclei (PAN), micronuclei (MNI). Results: Violations of FSG OF NGPBwere found according to all indices in patients with CHC, they were more pronounced in patients with concomitant DM-2. Conclusions: FSG NGPB is more disordered in CHC with concomitant DM-2. The reduction of IC in CHC with concomitant DM-2 is more pronounced in men. Reduction of IN in patients with CHC with and without DM-2 is a marker of violations of the second stage of realization of hereditary information. The tendency to change the components of the cytogenetic status of all examined patients due to the frequency of MNI was determined.

Imbalance of pro-inflammatory and anti-inflammatory cytokines was detected in 104 examined the patients with chronic hepatitis C. These changes were the most significant in patients with concomitant diabetes mellitus (DM) type II. Achievement of sustained viral response (SVR) under the influence of antiviral therapy depends on the state of cytokines system. This was evidenced by the detected correlation relationship between the levels of viral load (VL) in patients with concomitant diabetes mellitus type II, namely, direct weak one between IL-4 and VL (r=0.21) and reverse weak one between the level of IL-2 and VL (r=-0.04). Virus elimination rate and frequency influenced by anti-viral therapy (AVT) depends on the balance of pro-inflammatory and anti-inflammatory cytokines. This was shown in the research by detection of direct medium correlation relationship between VL and IL-4 (r= 0.31) and reverse medium correlation relationship between VL and IL-2 (r= -0.45).

The main indicators of quality of life in patients with chronic hepatitis C with concomitant diabetes mellitus type II were studied on the basis of SF-36. A sharp decrease in physical and mental health was observed in patients with combined comorbidity in comparison with the group of patients without concomitant diabetes mellitus type II. Improvement of the patients' quality of life by all parameters was detected under the influence of alpha-lipoic acid and lactulose use in addition to antiviral therapy.