Recent research on human microbiome provide opportunities to develop functional foods of new generation that can regulate intestinal microbiota and the biochemical status of the individual. the aim of the study was to determine the effect of individually designed nutrition on the intestinal microbiota and metabolic parameters of rats. outbred laboratory rats with obesity were randomly divided into 9 groups (n = 12) depending on the type of food ingredients taken orally for three months. the ratio of the intestinal commensal microorganisms main groups, as well as the lipid profile and the content of glucose, urea, calcium in the serum of animals were determined. It was shown that cholesterol level in the serum was reduced in experimental groups after consumption of lactobacilli suspension, blueberry juice, fermented milk drink based on lactobacilli, fermented milk drink with blueberry juice, sauerkraut. In most cases, the gut microbiome of experimental animals was characterized by a consistently high level of lacto and other beneficial bacteria and decreased amount of opportunistic microorganisms at the end of the experiment compared with animals in the control group. Based on the obtained data, we first proposed the principles of creating functional products by synergistically combining components of edible plants that act as prebiotics and microorganisms that act as probiotics for personalized use, targeted correction of intestinal microbiome and prevention of noncommunicable diseases. K e y w o r d s: functional foods, lipid profile, cholesterol, obesity, intestine microbiota, prebiotic and probio tic components.

Background: For Transcarpathian region, with a pronounced landscape diversity of territories and significant areas of nature reserves, well water is an important source of drinking water. Screening of the microelement composition of drinking well water in Transcarpathia has not been carried out before. The microelement composition of such well water can be considered as the natural (baseline) indicator of quality. Methods: We screened of the microelement (Cu,

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Consumption of edible plants satisfies a significant part of human body needs in macro-and micronutrients while biologically active substances contain strong antioxidant properties and reduce the risk of a number of diseases. Balanced nutrition and design of personalized diets and treatment rely on the data on the content of macro-and micronutrients and biologically active substances. We determined polyphenol and anthocyanin content in 22 species of local edible plants using modified spectrophotometric method with Folin-Ciocalteu reagent as well as chemical elements' content in a mixture of edible plants from 13 regions using standard procedures. We performed correlational analysis of the obtained data and analysis of the main components in OriginLab, developed regional models of chemical elements' content for a mixture of edible plants, and conducted cluster analysis using common tools in Python. The results of biologically active substances' study demonstrated that the highest content of polyphenolic compounds and anthocyanins was found in grape meal of Vitis vinifera L. The study of chemical elements' content demonstrated that edible plants from lowland areas are the best and revealed clear dependences of the elements on each other and geographical conditions. The analysis of the principal components confirmed this finding. Based on the obtained data, a number of regional models of chemical elements' content in a mixture of edible plants were built, tested, and evaluated. Obtained results are the basis for designing various diets, filling composite databases of the region's food, and creating the newest biologics-pharmabiotics.