Inaccurate lymph node staging affects treatment planning and may contribute to worse prognosis. A retrospective study was performed to confirm this hypothesis. Materials and methods: Data about patients diagnosed with stage I-III endometrial cancer between January 1, 2008 and December 31, 2009 (cases with multiple primary tumors were excluded) was extracted from cancer register of Kyiv City Clinical Oncology Centre. Hypothesis: The absence of lymphadenectomy in a patient with apparent early stage endometrial cancer, but with undiagnosed lymph node metastases may lead to understaging and undertreatment with worse prognosis and outcomes. Cancer-specific survival was the primary outcome. Results: From 564 patients assessed for eligibility, 61 were excluded. Cancer-related death was reported in 76 cases: 39 stage I, 14 -stage II, and 23 -stage III patients. Median cancer-specific survival was 27 months for stage I, 14 months for stage II, and 19 months for stage III (p = 0.01). Three-year cancer-specific survival rate was 33.3% for stage I, 0% for stage II, and 17.4% for stage III. Intergroup analysis showed a statistically significant difference in survival between stage I and stage II patients (p = 0.005), but there was no statistically significant difference in survival between stage III and stage I or II patients (p = 0.072 and p = 0.151, respectively). Conclusions: The same rates of cancer-specific survival may indicate that the presented cases of apparently early stage endometrial cancer were understaged and consequently undertreated. Further studies in larger groups of patients are needed.

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women with cancer based in, or associating with the MENAcountries. PAGs with a focus outside of women´s cancers and individual influencers or patient advocates were excluded from the search. Results A total of 10 documented legally-registered PAGs appeared in the search from nine countries. All these groups were easily accessible online. Only half (50%, 5/10) had an active homepage(activities not older than 3 months).All PAGS had at least one active SoMeC with recent activities not older than 2 weeks. More than half(60%, 6/10) had their homepage and SoMeCs in multiple languages. Within those groups none received their funding from membership fees, whereas most funding came from sponsorship and donations(100%, 10/10) and/or official government funding (70%, 7/10).Majority(90%, 9/10) had a clearly identifiable mission statement. Only half (50%, 5/10) had specified cooperation's with other advocacy groups within the region. Conclusion Although, further surveys are required, our pilot study shows a lack of online visibility and accessibility to PAGs in the MENA region. As a PARSGO global community, we need to focus on providing a unified and transparent platform to increase accessibility and dialogue for local and regional patient advocacy groups.

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Introduction/Background To evaluate pregnancy outcomes in patients diagnosed with stage I ovarian dysgerminoma who underwent a fertility-sparing surgery in a tertiary-care center in Monza, Italy. Methodology We performed a retrospective, observational study of women with a histologically confirmed diagnosis of ovarian dysgerminoma referred to our Institution from 1980 to 2020. We collected patients' characteristics, surgical procedures and postoperative management. Descriptive statistics were performed for baseline characteristics, while Fisher's exact test was used to investigate the association between type of surgery (ovarian cyst removal [CR] versus unilateral salpingo-oophorectomy [USO]), oncologic management (adjuvant chemotherapy [AC] versus follow-up [FU]) and pregnancy outcome. P<0.05 was considered significant. Results Of 131 patients diagnosed with ovarian dysgerminoma, 49 were diagnosed withearly-stage disease, treated with fertility-sparing surgery and received follow-up at our Institution. During follow-up 18 patients never planned a pregnancy or had already completed childbearing while 31 patients tried to conceive, with a live birth rate of 96.7%. No differences in delivery rate were found either between patients managed with CR only (3/31) and with USO (28/ 31), or between patients who received AC after surgery (12/ 31) and those who received follow-up only (19/31). Six patients reached physiologic menopause: mean age at menopause was 51.7 years. Conclusion Fertility-sparing surgical treatment is safe and feasible for patients with early-stage ovarian dysgerminoma. In our population, live birth rate was not affected by the type of surgery or postoperative oncologic management; the effect of fertility-sparing surgery for early-stage ovarian dysgerminoma on age at menopause should be further investigated.