Acute myocardial infarction (MI) is an important public health problem. Modern cardiology studies the role of such a premorbid background as undifferentiated connective tissue dysplasia (UCTD) in the pathogenesis of coronary heart disease (CHD) and MI in particular. Despite a large number of studies, the biochemical pathogenetic links of MI development against the background of UCTD remain unexplored. That is why our study aimed to analyze the stigmas of dysembryogenesis, coagulogram parameters, and platelet and uric acid (UA) levels as the most expected factors in the pathogenesis of MI with UCTD. The level of platelets in the peripheral blood of patients with UCTD (182.0 [161.0-265.0] x 109/l) did not differ reliably (but it was still significantly lower) from that in patients without UCTD [230.0 [206.0-309.0] x 109/l) (p>0.05). In particular, in 26 patients (57.8%) with UCTD, it was below the reference value. In those patients, who also have a large number of UCTD markers (10 or more), the stigma of "easy hematoma formation with insignificant damage" was most common. The level of UA in patients with Q-IM with UCTD was higher than normal and reliably higher than in the group without dysplasia (383.60 ± 33.82 vs. 292.11 ± 28.56, p<0.05). Increasing the level of UA provokes the activation of inflammatory processes in the coronary arteries, and leukocytelymphocytic infiltration of their tunica media, which, even at a low platelet level, leads to a cascade of mutually aggravating pathological changes that converge at the level of multivector endothelial damage.

The syndrome of undifferentiated connective tissue dysplasia (UCTD) is a genetically determined condition, the detailed clinical picture of which is formed during the first five years of life. The development of vegetative-vascular dystonia in UCTD is associated with a changed collagen structure, which leads to the appearance of numerous clinical manifestations that affect the psycho-emotional status of the child, especially if the leading syndrome is anxiety. The purpose of our study was to evaluate the method of integrative art therapy using fairytale therapy for the correction of psychosomatic disorders in children with UCTD syndrome. At the end of the 6 months course of integrative art correction with fairytale therapy, a significant (p < 0.05) decrease in the level of psycho-emotional stress was observed in the patients, amounting to 13.2 ± 0.5 points. As for the level of skin-galvanic response (SGR), a positive increase was found in the group of patients who underwent sessions of classical psychotherapy: 6.9 ± 0.01 conventional points (p > 0.05), while in patients who were treated with the method of integrative art therapy, the positive increase in SGR was reliable and amounted to 8.6 ± 0.01 conventional points (p < 0.05). So, the use of the method of integrative art-therapeutic correction of psychosomatic disorders in the form of fairytale therapy is accompanied by a significant decrease in the level of psycho-emotional tension and anxiety in children with UCTD syndrome.