Resistance to penicillin, other beta-lactams and macrolides does not seem to be a problem for Russia now. The high level of resistance to TMP-SMX considerably restricts its usage for the treatment of pneumococcal infections.

No abstract

In the triad of symptom complexes developing in mediastinitis and forming the mediastinal syndrome two of them, painful and toxic, determine the background of the disease being constant and pronounced. The third symptom complex, caused by compression of the neurovascular bundle, spreading purulent exudate, determines the nature and variety of symptoms that can imitate the independence of any nosological form: acute pancreatitis, gastric ulcer, myocardial infarction, etc., which have nothing to do with mediastinitis and complicating the diagnosis, leading to erroneous tactics and tragic outcome.

Sore throat is an acutely common health problem both in Russia and around the world as a whole. This is one of the most common reasons adults and children seek primary specialized care. The overuse and misuse of antibiotics, especially for viral infections of the respiratory tract, such as acute and exacerbation of chronic tonsillopharyngitis, greatly increases the risk of developing and spreading antibiotic resistance. Up to 80% of cases of sore throat have a viral etiology of the disease, and even when the infection is bacterial, except for pyogenic streptococcus, the vast majority of cases do not require systemic antibiotic therapy. However, antibiotics are still often and unreasonably prescribed to treat sore throats. In addition, topical antibiotics for sore throats are widely available over the counter over the counter. The clinical guidelines for the treatment of acute tonsillopharyngitis indicate that systemic antibiotic therapy is indicated for patients with sore throat of streptococcal etiology. Considering the growing antibiotic resistance in the world, much attention is paid to over-the-counter treatment of sore throat, which does not contain antibiotics in its composition, namely, the appointment of local anti-inflammatory drugs that can prevent the further development of the infectious process in the throat. The combined local and systemic effects, achieved through local delivery of flurbiprofen to the inflamed tissues in throat, have led to the development of flurbiprofen 8.75 mg in different types of dosage forms (including lozenges and sprays) to treat a sore throat.

The data about the prevalence of ENT organ diseases in children and the necessity of prescription of nasal forms of vasoconstrictors (decongestants) are presented. A review of the data about the mechanism of action of decongestants, safety and evidence base of their effectiveness in treatment of otorhinolaryngological diseases is presented. It is concluded that decongestants with a higher safety level are chosen a modern combined preparation containing antihistamine (dimethinden) and vasoconstrictor (phenylephrine) components.