This study illustrates the burden of MS on Russian patients and provides current data that are important for developing health policies.

Multiple sclerosis (MS) is one of the most important, disabling, and prevalent neurological disorders of young adults. It is a chronic inflammatory and neurodegenerative disease when autoreactive B and T cells have downstream effects that result in demyelination and neuronal loss. Anti-inflammatory disease-modifying therapies do have proven efficacy in delaying disease and disability progression in MS. While the progress in MS treatments has already improved the prognosis and quality of patients’ lives overall, there are some clear shortcomings and unmet needs in the current MS treatment landscape. The most promising means of MS treatment is selective immune reconstitution therapy (SIRT). This therapy is given in short-duration courses of immunosuppression, producing durable effects on the immune system and preventing nervous tissue loss. This review discusses the mechanisms of action and the data of clinical trials of cladribine tablets as an example of SIRT in MS. The clinical benefits of cladribine tablets in these studies include decreased relapse rate and disability progression with large reductions in lesion activity, and protection against brain volume loss. Whether all of these neurological findings are direct results of lymphocyte depletion, or if there are downstream effects on other, unknown, neurodegenerative processes are yet to be determined, but these clearly point to an interesting area of research.

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В настоящее время особое внимание при анализе результатов проводимого лечения уделяется методам оценки субъективного состояния пациента (Patient Reported Outcomes-PRO) [1]. Одним из наиболее широко используемых методов PRO является оценка качества жизни (КЖ) пациентов, связанного со здоровьем. Всемирная организация здравоохране-ния рекомендует активно использовать КЖ для оценки эффективности лечения, так как именно изменения КЖ во многом определяют выбор пациентами того или иного метода и результаты проводимой терапии [2]. Исследование КЖ является субъективным, поскольку отражает состояние больного человека пу