The detection of cardiac biomarkers is used for diagnostics, prognostics, and the risk assessment of cardiovascular diseases. The analysis of cardiac biomarkers is routinely performed with high-sensitivity immunological assays. Aptamers offer an attractive alternative to antibodies for analytical applications but, to date, are not widely practically implemented in diagnostics and medicinal research. This review summarizes the information on the most common cardiac biomarkers and the current state of aptamer research regarding these biomarkers. Aptamers as an analytical tool are well established for troponin I, troponin T, myoglobin, and C-reactive protein. For the rest of the considered cardiac biomarkers, the isolation of novel aptamers or more detailed characterization of the known aptamers are required. More attention should be addressed to the development of dual-aptamer sandwich detection assays and to the studies of aptamer sensing in alternative biological fluids. The universalization of aptamer-based biomarker detection platforms and the integration of aptamer-based sensing to clinical studies are demanded for the practical implementation of aptamers to routine diagnostics. Nevertheless, the wide usage of aptamers for the diagnostics of cardiovascular diseases is promising for the future, with respect to both point-of-care and laboratory testing.

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Harriet Beecher Stowe's novel Uncle Tom's Cabin, or Life Among the Lowly (1852) being the most powerful statement on the racial issue in the 19th century American literature, succeeded to incorporate and rethink everything that the national tradition had in stock on the problem of slavery and race relations. The Black racial / cultural identity model that was taking shape in the 18th century Anglo-American literature, later was being enriched and transformed throughout American (and African-American) literary history. Uncle Tom's Cabin became another crucial text (the next one after Jefferson’s Notes on the State of Virginia) that provided the emerging Black cultural / racial identity model with a new quality: it became universal, nationally recognized — and at the same time a point of controversy provoking endless debates and open for dynamic change and transformations, as was the case with anti-Tom literature and the ambivalent reception of Uncle Tom’s Cabin in African American literary tradition. The analysis of The Planter’s Northern Bride (1854) by Caroline Lee Hentz, a typical example of anti-Tom novels, gives an idea of the pro-slavery response to Uncle Tom’s Cabin. The final part of the paper is a survey of the main stages in African American response since the 1853 argument between Martin Delany and Frederick Douglass that became a matrix for the further polemic, and up to Henry Louis Gates’s subversive “double-voiced” interpretation of the novel which is in full agreement with the tendency to revise the role of white Abolitionists in the antislavery movement and African American history, typical for African American studies in the 1990s–2000s.

On December 8, 2022, an international academic conference dedicated to the year 1922 as an important milestone in the history of American and European Modernism was held at the Russian State University of Humanities (Moscow). The conference aimed at the cultural reconstruction of 1922 and was organized by the Department of Comparative-Historical Literary Studies, Russian State University for the Humanities, and A.M. Gorky Institute of World Literature of the Russian Academy of Sciences. American literary history occupied a prominent place in the program of the conference. The plenary session was devoted to T.S. Eliot, whose poem The Waste Land was published in 1922. Olga Polovinkina (Russian State University for the Humanities, A.M. Gorky Institute of World Literature of the Russian Academy of Sciences) spoke about the importance of the aesthetics of the music hall for the strcture The Waste Land. Igor Shaitanov (Russian State University of Humanities, The Russian Presidential Academy of National Economy and Public Administration) drew a parallel between The Waste Land and Evegny Zamyatin's Alatyr’. Vassily Tolmatchoff (Lomonosov Moscow State University) suggested a new interpretation of the “Love Song of J. Alfred Prufrock”. A.A. Astvatsaturov (St. Petersburg State University) considered T.S. Eliot’s modernist work in comparison with the creative attitudes and self-fashioning of Henry Miller. Alexandra Zinovieva (Lomonosov Moscow State University) spoke about Countess Marie Louise Elisabeth Larisсh von Moennich, the heroine of T.S. Eliot’s The Waste Land, and her participation in German and Austrian cinematographic projects of the late 1910s — early 1920s. Olga Panova (A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Lomonosov Moscow State University) reconstructed the year 1922 in the history of the Harlem Renaissance. Irina Morozova (Russian State University of Humanities) presented the year 1922 as an important period in the history of American pharaohmania. Olga Antsyferova (St. Petersburg State University) analysed the book 1922: Literature, Culture, Politics (ed. by Jean-Michel Rabaté; Cambridge University Press, 2015) showing how the methodology of historical simultaneity works on the material of culture studies.

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