Thanks to the use of nuclear energy a society lives under the conditions of increased radiation background. Malformations and other inherited diseases caused by damage to the genetic apparatus by low doses of irradiation appear even in the remote generations. It determines the need for research of the remote effects of irradiation of parents on their posterity. One of the most radiosensitive tissues is small intestine which is responsible for the last stages of digestion and absorption of nutrients. Therefore the aim of our work was the analysis of the role of satiety of the parents during irradiation in the assimilation of substrates of the protein origin in two generations of their posterity. Materials and methods: In vitro were studied parameters of transport of free glycine and "peptide" glycine formed from glycyl-glycine in the small intestine of the 2nd generation of posterity of male rats, that were irradiated by a dose 0,5 Gy after taking meal, and intact females. Results: Parameters of the transport of the free glycine and "peptide" glycine in the small intestine of the 2nd generation of posterity of irradiated satiety male rats are lower than corresponding parameters in the 1st generation and in the intact groups but are in the borders of active component of transport. Stability of transport of the free glycine and "peptide" glycine are higher than in the corresponding intact groups. Conclusions: In comparison with the corresponding data for 2nd generation of irradiated fasting male rats, satiety of the male-predecessors lead to the stabilization of the activity of transport system as for free glycine, so for the "peptide" glycine both in the small intestine of their posterity. Apparently, the protective effect of the presence of food in the gastrointestinal tract of precursor at exposure is realized by stabilizing of the activity of transport system for free glycine and "peptide" glycine both in the small intestine of two generations of posterity, and maintaining its work at the level necessary and sufficient for normal body functioning.

The study of the assimilation of glucose and maltose in the small intestine of two generations of posterity of irradiated male rats received with a food the milled milk thistle fruits after irradiation. Methods: Exposition of male rats performed once by the help of telegamma-setting "AGAT-R1", dose was 120 rad/min, field 20×20, distance from the source of irradiation to the field=75 cm, dose-0.5 Gy, exposure-32 sec. Accumulating mucosa preparations (APS) produced by the method of Ugolev et al. APS incubated for 1 hour at t=37ºC in the oxygenated medium. As the incubation medium were used solutions 10 mmol/l of glucose and 5 mmol/l of maltose that were made on the Ringer solution pH 7.4. In all incubation medium the bile was added. The concentration of free glucose and M-glucose formed due to the hydrolysis of maltose was determined using method described in ref. Colorimetrically on photoelectrocolorimeter-CFC-2MP, λ=625 nm. The statistical processing of the obtained data was conducted using "Primer Biostatistics" software. Results: The 2 nd generation of the offspring from the males, which received milk thistle in the food immediately after irradiation, showed the high activity of the transport system for the free glucose and system providing transport of M-glucose produced by the hydrolysis of maltose both. This activity is higher than in the corresponding groups of the 1 st generation (p<0,0001) and higher than corresponding data in all experimental groups of 2 nd generation (except only group of the posterity of the male rats got milk thistle fruits before irradiation). Conclusion: The use by predecessors of milk thistle after irradiation leads to the radio corrective effect on the systems of transport of glucose and maltose both exactly in second generation of their posterity.