Bone cancers occur mainly in adolescents and young adults, and benign lesions are more frequent than malignant ones. The most common malignant tumors include osteosarcoma, Ewing's sarcoma and chondrosarcoma. The course of the disease may not be obvious and symptoms may be ambiguous, so it is important to catch them early and take appropriate action.  Laboratory tests such as CRP, ESR, LDH, ALP may prove useful in the diagnosis of bone neoplasms in children. All children with suspected malignant bone cancer should undergo an x-ray examination. MRI, CT scans are performed to expand the diagnosis and determine the extent of the disease. The basis of diagnosis is histopathological examination. The result of this study is very important in the selection of therapeutic procedures, it influences decisions regarding the scope and degree of radicality of the operation. It is crucial that the entire diagnostic process is carried out in highly specialized centers that have extensive experience in the diagnosis and treatment of malignant bone tumors in children. It is most beneficial to conduct diagnosis and treatment at the same center, and preferably by the same team of specialists. This team should include doctors from orthopedics, radiology, oncology, radiation therapy and pathomorphology. Conducting diagnosis and treatment in highly specialized centers has a positive effect on the prognosis and quality of life of patients. The purpose of this article is to highlight the early and uncharacteristic symptoms of bone cancer in children and to present the complexity of the diagnostic process, as well as the importance of carrying it out in highly specialized centers with extensive experience in treating pediatric bone malignancies.

Introduction: The human digestive tract contains 38 trillion bacteria in the colon. Physiologically, there is much less of them in other parts of digestive tract. The concentration of bacterial colonies grows along the intestine. Small intestinal bacterial overgrowth (SIBO) is characterized by an increased number of bacteria in the small intestine that correlates with gastrointestinal symptoms. The main symptoms of SIBO are bdominal bloating and diarrhea. Diagnostic methods used in SIBO include measuring methane or hydrogen levels. However, the use of antibiotics is prevalent, there is still a necessity to search for the gold standard of treatment.     Objective: The purpose of this paper is to review the current knowledge on the management of patients with proliferative small intestinal bacterial flora syndrome. Particular attention was paid to the types of diagnosis and treatment of this ailment in recent years.   Material and methods: The review includes publications published in 2001- 2022. Data were collected using PubMed or az published online American College of Gastroenterology (ACG) 2020 guidelines.   Results: SIBO is an incompletely understood disease. Its symptoms are nonspecific and found in many gastrointestinal disorders, and its diagnosis is not fully specified. The gold standard for diagnosis is the collection of a small bowel aspirate during endoscopic examination. Antibacterial treatment is given empirically, mainly rifaximin, while other types of treatment are not strongly established in the publications.   Conclusions: The lack of standardized management and the lack of sufficient evidence for the effectiveness of current methods make SIBO a recurrent complaint. All above aspects confirm that SIBO requires a lot of research to provide better life quality for these patients.

Introduction and purpose: Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA syndrome) is the most common periodic fever condition in child age. Discussed syndrome is generally a self-limited condition, but it can significantly decrease the quality of child’s life. It can be also challenge for parents, as well as medical professionals. Knowledge of the syndrome is very important among many specialists because early detection is the basis of the correct differentia and proper treatment. Many researches has been made to explain the genetic and immunologic elements which play a significant role in the pathogenesis of PFAPA, but it is not fully undestood. This review will focus on current knowledge regarding the pathogenesis of PFAPA, as well as surgical and conservative treatment strategies. Material and methods: This review was based on available data collected in the PubMed database and published between 2013 and 2022. The study was conducted by reviewing key words as follows: "PFAPA","treatment", "diagnosis","tonsillectomy". Results: The diagnosis of PFAPA syndrome consists of a typical clinical presentation, but sometimes diagnosis of this syndrome can be problematic. Some clinical criteria can be useful. We have vary of treatment arms depends on clinical targets. Depite that PFAPA is self limiting syndrome which can dissappear in later years of children’s life.   Conclusions: PFAPA syndrom is rare disease, but is very important to put emphasis on knowledge about it. Early diagnosis of this syndrome can make physicians send patient to specialized ward, and it will be possible to start proper and efficient treatment. It is a question of the future that we will get more patophysiologic knowledge about this disease.

ABSTRACT Introduction: The COVID-19 pandemic has been accompanying us in our daily lives for more than 2.5 years and so far there are no indications that it will leave us soon. Updating information and knowledge about it is therefore still incredibly important. Sars-CoV-2 is a virus with a high affinity for the respiratory system, so it is worth tracing its correlations with one of the more common lung diseases, asthma. Patients with this disease are concerned about whether they are at risk of contracting COVID-19 more frequently and severely, whether they face a higher risk of death if infected and how the pandemic will affect exacerbations of their underlying disease. For physicians who encounter the virus on a daily basis, it is important to know how well to manage asthmatic patients if COVID-19 is confirmed in them. State of knowledge: In medicine, not everything is clear-cut. Much depends on our patient's age, condition and other comorbidities. And also on his/her adherence to medical advice, type and degree of asthma control. In this article, we will address all these aspects and summarise the current knowledge on the interplay between COVID-19 and asthma. Conclusions: With the review of recent reports collected here, it can be thought that asthma is not an independent factor for either a higher frequency or severity of COVID-19, but neither does it affect the higher risk of death with Sars-CoV-2 infection. In terms of treatment, it is important not to interrupt the current therapy and to maintain good asthma control. This is the most optimal treatment and reduces the risk of severe COVID-19. Drugs registered for the treatment of asthma are safe and, moreover, it has been suggested that corticosteroids protect against infection to some extent.

Introduction Nowadays it is pointed out how important it is to take care of both mental and physical health. It is also undeniable that one affects the other and vice versa. That is why it is so important to nurture your body. Yoga as one of the physical activities has a proven effect on psychosomatic symptoms. Yoga is increasingly recommended mainly to relieve anxiety or stress. It brings great solace and even greater attentiveness. Lifestyle activities are increasingly considered an important component of treatment.   State of knowledge Medical conditions such as dementia, Parkinson's disease, headaches, PTSD, depression are mainly treated with drugs. Yoga, as a non-pharmacological treatment, alleviates psychological conditions, as it reduces stress, anxiety, depressive symptoms, and enhances attentiveness to one's self, self-control and a different perspective on traumatic situations.   Conclusions A review of the following works has shown the effects of yoga on mental health and common neurological conditions. With regular practice, it is possible to develop cognitive function, reduce the intensity and frequency of headaches. In Parkinson's disease, mindfulness exercises lead to an increase in muscle strength, a decrease in muscle tremors, and therefore improved rehabilitation. Most of the examples below mention a decrease in anxiety, stress, depressive symptoms and an increase in mindfulness, greater emotional and physical flexibility. The works cited point out that more in-depth research is needed to delve deeper into the effects of yoga on health.