The article represents a three-year study of the effect of bioactive substances as part of growth promoting factors on the course of physiological processes in cucumber crops when grown under protected ground conditions (greenhouse) in the StavropolTerritory. The enhanced metabolism of the plants resulted in increase of crop yields. The studies revealed that the highest yield of cucumber exceeding the control by 14.7% was obtained at combined use of growth factors, namely Radifarm, Benefit, and Megafol.