thousand kernel weight. The variety MIP Azart was differed from the other varieties in the ratio of main yield structural elements. Thus, the newly developed spring barley varieties had differences from each other in pattern of yield and yield-related traits manifestation. According to the GYT biplot model the spring barley variety MIP Bohun was the nearest to the "ideal genotype" in terms of yield*traits combination. The practical worth of the identified patterns is that the new varieties, due to the relatively different pathways of yield formation, will complement each other under unfavorable environmental factors in the production conditions. On the whole, it was shown effectiveness of combining statistical and graphical approaches to comprehensive evaluation the breeding improvement for yield and yield-related traits in new varieties compared to ones created in the previous period.

The aim — to improve the treatment results of patients with a bdominal aorta aneurysm (AAA) by reducing their neurological complications risk.Materials and methods. During 2001 — 2018 an ultrasound duplex scan of carotid arteries was performed for 847 patients with AAA. In 84 (9.9 %) patients, concomitant stenosis of the internal carotid artery > 75 % was found. The average age of the patients was 61.3 ± 2.7 years. Men prevailed among the patients (78 (92.9 %)). All patients underwent a comprehensive examination. One‑stage carotid endarterectomy and open resection of AAA were performed in 25 (29.8 %) patients, staged carotid endarterectomy with the second stage of AAA repair — in 24 (28.6 %), staged AAA resection with the second stage of carotid arteries revascularization — in 16 (19.1 %) patients. Two‑stages intervention was performed in 7 (8.3 %) patients with a combination of an internal carotid artery stenosis, AAA and peripheral artery disease , the first stage was intervention on the carotid arteries, on the second stage (from 3 to 7 days) the reconstruction of the abdominal aorta and arteries of the lower extremities were done. In 7 (8.3 %) patients with concomitant coronary artery disease the two‑stages intervention was performed, with the primary one‑stage revascularization of the carotid and coronary arteries, and in 5 (6.0 %) — three‑staged reconstruction in the following sequence: carotid endarterectomy, coronary artery bypass grafting, reconstruction of the abdominal aorta.Results and discussion. No case of cerebrovascular accident in patients undergoing primary revascularization of the carotid arteries, either simultaneous, or staged was noted. In a group of patients who underwent an intervention on the abdominal aorta without carotid and coronary pathology correction, 1 patient developed ischemic stroke with a fatal outcome. Another 1 patient had myocardial infarction in the first postoperative day. The overall level of neurological complications was 1.2 %. The duration of hospitalization was 11.7 ± 0.7 days for patients with simultaneous interventions and 19.5 ± 0.6 days for staged treatment, stay duration in the intensive care unit were 2.1 ± 0.3 and 4.3 ± 0.5 days respectively.Conclusions. During planning of interventions on AAA the screening test of even clinically non‑manifested arterial segments (carotid and coronary arteries, arteries of the lower extremities) is necessary according to multi‑vascular nature of atherosclerotic lesions. The primary revascularization of the carotid arteries (symptomatic stenoses over 75 %, asymptomatic stenoses with high embolic risk) has to be done prior to the reconstruction of the AAA. The method of one‑stage operation on carotid arteries and abdominal aorta with a weighted risk assessment and plan of aortic intervention is more appropriate.

Familial combined hyperlipoproteinemia is considered one of the most common genetic hyperlipidemias in the general population with estimated prevalence 0.5 %–2.0 % of all inherited dyslipidemias. This disorder frequently coexists with other metabolic diseases such as obesity, insulin resistance, hypertension, non-alcoholic fatty liver disease. Association of hyperlipoproteinemia and type 2 diabetes mellitus can be explained due to the fact, that familial combined hyperlipoproteinemia is caused by genetic variability, including genes encoding the upstream transcription factor 1. The last regulates nearly 40 genes implicated in lipid, lipoprotein and carbohydrate metabolism, as well as immune response. Polymorphism in the upstream transcription factor 1 is strongly associated with dyslipidemia, impaired glucose tolerance, insulin resistance, and type 2 diabetes mellitus. In this report on example of clinical case we want to pay attention of practitioners to the problem of familial causes of hyperlipidemias, which leads to early onset of atherosclerosis, cardiovascular disease, and, finally, to premature disability of the affected person. Because of the frequent overlapping with the features of metabolic syndrome, this serious disorder is often not recognized and treated timely. Our patient was a 43 year old male, who was referred to the clinic with complaints of angina pain and dyspnoea provoked by minimal physical exertion, palpitations, irregular heartbeats, lower extremities and face oedema. At the age of thirty in the patient have developed type 2 diabetes mellitus, during last 7 years it was insulin dependent, the course was severe, glycaemia was poorly controlled by the therapy. Also he had essential hypertension III grade. At the age of 37 years the patient suffered from ST-elevated myocardial infarction, one year later occurred recurrent myocardial infarction. His family history was strongly positive for atherosclerosis and cardiovascular disease, as well as type 2 diabetes mellitus. In laboratory testing the fasting blood sample revealed a grossly lipemic serum, with total cholesterol level 17.75 mmol/L, very low density lipoproteins 3.41 mmol/L, low density lipoproteins 13.64 mmol/L, high density lipoproteins 0.7 mmol/L. Diagnosis: «Familial combined hyperlipoproteinemia (Fredrickson type 2B). Acute coronary syndrome: Unstable angina IIB. Postinfarction (STEMI 2014, 2015) cardiosclerosis. Essential hypertension III degree III stage. Heart failure with left ventricular systolic and diastolic dysfunction, EF 36 %. III functional class NYHA. Stage D AHA. Risk score 4 (very high).Type 2 diabetes mellitus, insulin dependent, severe course. Non-alcoholic fatty liver, 2 degree. Nodular goitre I degree, euthyroid state» was established. Management of this patient includes lifestyle modification and combined lipid lowering therapy in high doses: rosuvastatin and choline fenofibrate. Unfortunately, in this case target levels of cholesterol and triglycerides were not achieved: minimal level of total cholesterol was 12.29 mmol/L, and level of triglycerides was 41.48 mmol/L. Risk estimates based on risk charts, scores, or functions used in the general population, probably grossly underestimate the real risk of this patient with familial combined hyperlipoproteinemia. Coexistence of extremely high level of cholesterol and type 2 diabetes mellitus significantly aggravates and advances each other's course, comparing with the isolated disorders.