Congenital central hypoventilation syndrome is a very rare genetic disorder. The disease involves respiratory failure associated with impaired central control of the breathing process. Hirschsprung’s disease is the cause of congenital intestinal obstruction as a result of the agenesis of ganglion cells in the submucosal and myenteric plexuses. If congenital central hypoventilation syndrome and Hirschsprung’s disease occur simultaneously, Haddad syndrome is diagnosed. A male infant was born at 37 weeks of gestation in a moderate general condition. Due to increasing respiratory effort and increased demand for oxygen, the newborn was intubated and mechanically ventilated. During an extubation attempt, respiratory symptoms intensified, and CO2 was accumulating on blood gas test. Genetic tests revealed a mutation in the PHOX2B gene, which confirmed congenital central hypoventilation syndrome. Lack of meconium and enteral nutrition intolerance were observed. Hirschsprung’s disease was diagnosed on the basis of intestinal biopsy. Loop ileostomy was created at 5 weeks of life. Due to coexistence of congenital central hypoventilation syndrome and Hirschsprung’s disease, Haddad syndrome was diagnosed.

Background: Pregnancy in women who are organ recipients has long been a controversial issue due to the lack of data on the safety of immunosuppressive drugs for the developing foetus. Scientific data show that the effect of immunosuppressants on the foetus causes an impairment of T and B lymphocyte function and a reduction in their total number. For this reason, some authors recommend delaying the obligatory immunization of infants. The aim of the study is to analyse the impact of chronic immunosuppressive therapy used during pregnancy by women after organ transplantation on the effectiveness of anti-viral vaccinations in the children of these women. Methods: Concentrations of post-vaccination IgG antibodies (measles, HBV, polio) in 18 children of post-transplant mothers (9KTRs; 9LTRs) were determined using the ELISA method. The results were compared with the control group (n = 21). The incidence of vaccination AEs was also analysed. Results: There were no significant differences between the analysed groups in the concentrations of antibodies against HBV, measles and polio (p > 0.05). Conclusions: No difference was observed in the immunogenicity of HBV, polio and measles vaccinations between children of post-transplant mothers and the general population. The immunization of children of post-transplant mothers is safe, and the percentage of adverse post-vaccination events does not differ from the general population. The obtained study results do not indicate the necessity for modifying the vaccination program for HBV, measles, and polio in this group of patients.