Purpose of Review We review recent evidence on suicide among older adults, examine risk factors contributing to vulnerability to late-life suicide, and summarize possible interventions. Recent Findings We found a steadily increasing rate of late-life suicide in the USA in the past decade. Evidence supporting the integration of depression care managers into primary care for risk reduction is among the strongest to date. Pharmacologic and neuromodulation studies should be considered in geriatric depression complicated by suicidality. Broad societal campaigns about suicide education, as well as active outreach to psychiatric patients after discharge or a suicidal crisis, prevent suicidal behavior. Growing research supports an integrative multidisciplinary approach. Summary Suicide is a complex and multifaceted behavior with numerous casual points for intervention. Access to deadly means, presence of depression, disease, disability, and social disconnection are factors that increase vulnerability. Quality geriatric care, regular screening in primary and emergency care settings, and a multidisciplinary approach are necessary to mitigate risk factors. The COVID-19 pandemic amplifies need for a more aggressive approach.

Nifurtimox is recommended for the treatment of Chagas disease; however, long-term follow-up data are scarce. This prolonged follow-up phase of the prospective, historically controlled, CHICO clinical trial evaluated seronegative conversion in pediatric patients aged <18 years with Chagas disease who were followed for 4 years after nifurtimox treatment.

BACKGROUND: Pain is one of the most common adverse events after surgery. Regional anesthesia techniques are effective for pain control but have limited duration of action. Liposomal bupivacaine is a long-acting formulation of bupivacaine. We conduct this systematic review to assess whether liposomal bupivacaine may prolong the analgesic duration of regional anesthesia compared to conventional local anesthetic agents. METHODS: We systematically searched PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE (Ovid), Cumulative Index to Nursing and Allied Health Literature (CINAHL), Google Scholar, Web of Science citation index, US clinical trials register, and recent conference abstracts for relevant studies. RESULTS: We identified 13 randomized controlled trials that compared the use of liposomal bupivacaine to conventional local anesthetics in regional anesthesia. There were 5 studies on transversus abdominis plane (TAP) block, 3 of which reported longer duration of analgesia with liposomal bupivacaine. One study reported comparable analgesia with liposomal bupivacaine TAP block compared to TAP block catheter. There were 3 studies on brachial plexus block, 2 of which reported that liposomal bupivacaine may provide longer analgesia. Studies on other techniques did not report significantly longer analgesia with liposomal bupivacaine. CONCLUSIONS: Currently, there is limited evidence suggesting that liposomal bupivacaine provides longer analgesia than conventional local anesthetics when used in regional anesthesia. The analyses of multiple studies on liposomal bupivacaine for TAP blocks and brachial plexus blocks have yielded conflicting results. As a result, no definitive conclusions can be drawn about its efficacy compared to plain bupivacaine.

The “global IR” debate lacks systematic data on scholarship in different world regions, particularly outside the Web of Science (WoS). To close this gap, we compare 2,362 articles published in seventeen journals between 2011 and 2015. We map each article's overall approach, main theories, and substantive issue area. These content data are combined with information on the author's biographical background. Crucially, our sample also includes journals from East Asia, Africa, Latin America, Europe, and North America not indexed in the WoS. We find a bifurcated Transatlantic core of IR, with an emphasis on quantitative-rationalist research on one side compared to more constructivist and critical theorizing on the other. Journals outside the core more often feature articles with a descriptive approach, and this tendency is not limited to atheoretical works. Theoretical paradigms vary in popularity between regions. Many articles draw on multiple theories, including concepts from adjacent fields, which supports the notion of analytical eclecticism. Yet explicitly “non-Western” theorizing remains rare. To explore the influence of academic socialization, we compare subsamples within journals. The origins of doctoral degrees indeed seem linked to research preferences, suggesting that journals can become more well-rounded by publishing works by authors from diverse academic backgrounds. El debate sobre las “relaciones internacionales globales” carece de datos sistemáticos sobre los estudios en diferentes regiones del mundo, especialmente fuera de la plataforma Web of Science (WoS). Para cubrir esta falta de datos, comparamos 2362 artículos que se publicaron en 17 revistas entre 2011 y 2015. Realizamos un esquema del enfoque general, las teorías principales y el ámbito temático sustancial de cada artículo. Estos datos del contenido se combinan con información sobre los antecedentes biográficos del autor. Crucialmente, nuestra muestra también incluye revistas de Asia oriental, África, América Latina, Europa y Norteamérica que no están indexadas en la plataforma WoS. Observamos una base transatlántica bifurcada de las relaciones internacionales, con un énfasis en la investigación cuantitativa y racionalista por un lado, en comparación con una teorización más constructivista y crítica por el otro. Con más frecuencia, las revistas que no se encuentran en la base incluyen artículos con un enfoque descriptivo, y esta tendencia no se limita a las obras no teóricas. Los paradigmas teóricos varían en materia de popularidad entre las regiones. Muchos artículos recurren a varias teorías e incluyen los conceptos de campos adyacentes, lo cual respalda la noción del eclecticismo analítico. No obstante, la teorización que es explícitamente “no occidental” continúa siendo escasa. Para analizar la influencia de la socialización académica, comparamos submuestras dentro de las revistas. En efecto, los orígenes de los doctorados parecen estar relacionados con las preferencias de investigación, lo cual sugiere que las revistas pueden tornarse más integrales publicando obras de autores de distintos antecedentes académicos. Le débat sur les « RI mondiales » manque de données systématiques sur les recherches menées dans différentes régions du monde, tout particulièrement hors de Web of Science (WoS). Pour combler cette lacune, nous avons comparé 2 362 articles publiés dans 17 revues entre 2011 et 2015. Nous avons cartographié l'approche globale, les principales théories et le domaine de la problématique substantielle de chaque article. Ces données sont alliées à des informations sur le parcours biographique des auteurs. Mais surtout, notre échantillon inclut aussi des revues issues d'Asie de l'Est, d'Afrique, d'Amérique latine, d'Europe et d'Amérique du Nord qui ne sont pas indexées dans WoS. Nous avons d'une part décelé un noyau de RI transatlantique dichotomique, une facette mettant l'accent sur les recherches quantitatives/rationalistes alors que l'autre se concentre sur une théorisation plus constructiviste et critique. Les revues hors de ce noyau présentent plus souvent des articles adoptant une approche descriptive et cette tendance ne se limite pas aux travaux athéoriques. Les paradigmes varient en popularité entre les régions. De nombreux articles s'appuient sur plusieurs théories, notamment sur des concepts issus de domaines adjacents, ce qui contribue à la notion d’éclectisme analytique. Pourtant, la théorisation explicitement « non occidentale » reste rare. Nous avons comparé des sous-échantillons au sein des revues pour explorer l'influence de la socialisation académique. Les origines des diplômes de doctorat semblent en réalité associées à des préférences de recherche, ce qui suggère que les revues pourraient devenir plus équilibrées en publiant des travaux d'auteurs aux divers parcours académiques.

4. Warner LL, Hunter Guevara LR, et al. Creating a model to predict time intervals from induction of labor to induction of anesthesia and delivery to coordinate workload.