HighlightsROS levels assessed in peripheral and central sensory neurons following paclitaxel.Increased ROS levels seen in non-peptidergic neurons prior to paclitaxel-induced pain.Elevated ROS levels in spinal neurons, but not microglia/astrocytes, after paclitaxel.Assayed activity of main antioxidant enzymes during paclitaxel-evoked pain timecourse.Inadequate antioxidant response suggests elevated ROS sustains paclitaxel-evoked pain.
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