This study examined types of and reactions to loss experienced by a sample of 162 undergraduate and graduate students in the United States amid the COVID-19 global pandemic. Results indicated students reported an average of 6.33 losses with loss of normalcy being the most prominent. The number of losses experienced was a significant predictor of loss of control and avoidance. A significant positive relationship was revealed between spirituality and positive reappraisal whereas a significant negative correlation was identified between spirituality and loss of control and avoidance. Age was also negatively associated with expressions of avoidance and loss of control. Finally, students who attended faith-based institutions reported higher levels of positive reappraisal and lower levels of loss of control. Results suggest the need for educators and mental health practitioners to assess non-death losses among college students and provide supportive interventions aimed at promoting psychosocial-spiritual coping and resilience during and following a pandemic.