Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary brain tumour in humans and has a very poor prognosis. The existing treatments have had limited success in increasing overall survival. Thus, identifying and understanding the key molecule(s) responsible for the malignant phenotype of GBM will yield new potential therapeutic targets. The treatment of brain tumours faces unique challenges, including the presence of the blood brain barrier (BBB), which limits the concentration of drugs that can reach the site of the tumour. Nevertheless, several promising treatments have been shown to cross the BBB and have shown promising pre-clinical results. This review will outline the status of several of these promising targeted therapies.

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The idea that language can affect how we see the world continues to create controversy. A potentially important study in this field has shown that when an object is suppressed from visual awareness using continuous flash suppression (a form of binocular rivalry), detection of the object is differently affected by a preceding word prime depending on whether the prime matches or does not match the object. This may suggest that language can affect early stages of vision. We replicated this paradigm and further investigated whether colour terms likewise influence the detection of colours or colour-associated object images suppressed from visual awareness by continuous flash suppression. This method presents rapidly changing visual noise to one eye while the target stimulus is presented to the other. It has been shown to delay conscious perception of a target for up to several minutes. In Experiment 1 we presented greyscale photos of objects. They were either preceded by a congruent object label, an incongruent label, or white noise. Detection sensitivity (d’) and hit rates were significantly poorer for suppressed objects preceded by an incongruent label compared to a congruent label or noise. In Experiment 2, targets were coloured discs preceded by a colour term. Detection sensitivity was significantly worse for suppressed colour patches preceded by an incongruent colour term as compared to a congruent term or white noise. In Experiment 3 targets were suppressed greyscale object images preceded by an auditory presentation of a colour term. On congruent trials the colour term matched the object’s stereotypical colour and on incongruent trials the colour term mismatched. Detection sensitivity was significantly poorer on incongruent trials than congruent trials. Overall, these findings suggest that colour terms affect awareness of coloured stimuli and colour- associated objects, and provide new evidence for language-perception interaction in the brain.

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Understanding how, why, and whether the trade-offs and tensions around simultaneous implementation of the Sustainable Development Goals are resolved both sustainably and equitably requires an appreciation of power relations across multiple scales of governance. We explore the politics and political economy of how the nexus around food, energy, and water is being governed through initiatives to promote climate-smart agriculture (CSA) as it moves from the global to the local. We combine an analysis of how these interrelationships are being governed (and ungoverned) by key global institutions with reflection on the consequences of this for developing countries that are being targeted by CSA initiatives. In particular, we look at Kenya as a country heavily dependent on agriculture, but also subject to some of the worst effects of climate change and which has been a focus for a range of bilateral and multilateral donors with their preferred visions of CSA. We draw on strands of literature in global environmental politics, political ecology, and the political economy of development to make sense of the power dynamics that characterize the multiscalar politics of how CSA is translated, domesticated, and operationalized in practice.We currently lack global governance institutions and processes in the area of food and agriculture capable of addressing the interrelationships between the global food system, on one hand, and environmental challenges around water, energy, and climate change, on the other. Instead, fragmentation persists across institutions and agencies with responsibility for these areas, despite growing acknowledgment of the complex interlinkages that characterize the nexus around water, energy, and food (WEF) in particular. The urgency of addressing these issues is underscored by the recognition that the Sustainable Development Goals (SDGs) cannot be achieved in isolation from one another. To simultaneously and effectively achieve goals 2 (hunger), 6 (water), 7 (energy), 13 (climate change), and 15 (life on land) presupposes an institutional capacity and willingness to act on and govern those relationships in more integrated ways across all levels of governance from the local to the global, crossing scales and sectors (United Nations Environment Programme 2007).