The remodeling of the microtubule cytoskeleton underlies dynamic cellular processes, such as mitosis, ciliogenesis, and neuronal morphogenesis. An important class of microtubule remodelers comprises the severases—spastin, katanin, and fidgetin—which cut microtubules into shorter fragments. While severing activity might be expected to break down the microtubule cytoskeleton, inhibiting these enzymes in vivo actually decreases, rather increases, the number of microtubules, suggesting that severases have a nucleation-like activity. To resolve this paradox, we reconstitutedDrosophilaspastin in a dynamic microtubule assay and discovered that it is a dual-function enzyme. In addition to its ATP-dependent severing activity, spastin is an ATP-independent regulator of microtubule dynamics that slows shrinkage and increases rescue. We observed that spastin accumulates at shrinking ends; this increase in spastin concentration may underlie the increase in rescue frequency and the slowdown in shortening. The changes in microtubule dynamics promote microtubule regrowth so that severed microtubule fragments grow, leading to an increase in the number and mass of microtubules. A mathematical model shows that spastin’s effect on microtubule dynamics is essential for this nucleation-like activity: spastin switches microtubules into a state where the net flux of tubulin onto each polymer is positive, leading to the observed exponential increase in microtubule mass. This increase in the microtubule mass accounts for spastin’s in vivo phenotypes.

A consistency check for any UV complete model for large N QCD should be, among other things, the existence of a well-defined vector and scalar mesonic spectra. In this paper, we use our UV complete model in type IIB string theory to study the IR dynamics and use this to predict the mesonic spectra in the dual type IIA side. The advantage of this approach is two-fold: not only will this justify the consistency of the supergravity approach, but it will also give us a way to compare the IR spectra and the model with the ones proposed earlier by Sakai and Sugimoto. Interestingly, the spectra coming from the massless stringy sector are independent of the UV physics, although the massive string sector may pose certain subtleties regarding the UV contributions as well as the mappings to actual QCD. Additionally, we find that a component of the string landscape enters the picture: there are points in the landscape where the spectra can be improved somewhat over the existing results in the literature. These points in the landscape in-turn also determine certain background supergravity components and fix various pathologies that eventually lead to a consistent low energy description of the theory.

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Many recent works on large N holographic QCD in the planar limit have not considered UV completions, restricting exclusively towards analyzing the IR physics. Due to this, the UV problems like Landau poles and divergences of Wilson loops including instabilities at high temperatures have not been addressed. In some of our recent papers, we have discussed a possible UV completion, which is conformal in the UV and confining in the far IR, that avoids the Landau poles and the Wilson loop divergences. In this paper we give a general field theoretic considerations of this including the complete RG flow. We extend our UV complete model to study scenarios both above and below the deconfinement temperature and argue how phase transition in our model should be understood. Interestingly, because of the UV completion, subtle issues like instability due to negative specific heat do not appear.

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