The aim of the present study was to evaluate Terminalia mantaly gum as a polymer in the formulation of floating metronidazole microbeads. Terminalia gum was extracted and characterized using mateial, proximate and pasting properties. Terminalia gum in combination with sodium alginate at varying conccentrations (0-80 %w/w)was used in preparing the microbeads by ionotropic gelation using zinc chloride as the chelating agent. The microbeads were evaluated using shape, size, swelling, bouyancy, entrapment efficiency, drug release profiles and kinetic modelling. The microbeads were spherical to ovoid in shape with sizes ranginf from 1093 to 1209 micrometer. The swelling index was 5 to 184 % and it increased with increase in gum concentration. The total floating time was highest (175.5 h) for formulations having 20 %w/w gum and least (5.5 h) for those with 80 %w/w gum. The entrapment efficiency generally increased with increase in gum concentration up to 40 % and then reduced. The microbeads showed controlled release patterns of metronidazole with least t80 greaer than 5.8h. The drug release kinetics fitted Korsmeyer-Peppas model with non-Fickian anomalous diffusion mechanism. Terminalia mantaly gum can be further developed for use as co-polymer in the formulation of floating metronidazole microbeads.
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