BACKGROUND: Work-related musculoskeletal disorders (WMSD) account for a loss of GDP in most countries. The oil sector is the largest and most economically relevant industry in Nigeria, yet the impact of WMSD on workers in this industry is unknown. OBJECTIVE: To assess the prevalence, pattern and predictors of WMSD among oil workers in Nigeria. METHODS: This exploratory study was conducted in oil producing companies in Nigeria. Nordic Musculoskeletal Questionnaire was used to assess WMSD, while risk factors and demographic variables were obtained through an interview. Obtained data were analysed using descriptive statistics, Chi-square and logistic regression at α=0.05 RESULTS: A total of 198 (138 male, 60 female) oil workers aged 40.3±10.1 years participated in this study. The prevalence of WMSD was 88.8%, and was most common around the low-back (51.5%), and neck (44.4%) regions. There was a significant association between WMSD and each of duration of service (X2 = 45.44, p = 0.020), awkward neck postures at work (X2 = 12.46, p = 0.006), inadequate training on injury prevention (X2 = 11.98, p = 0.007), and continuing to work while feeling discomfort (X2 = 10.83, p = 0.013). Post-hoc analysis revealed that being a male oil worker (OR = 1.17, p = 0.037) and continuing to work while feeling discomfort or pain (OR = 2.23, p = 0.048) were the significant predictors of WMSD. CONCLUSIONS: Approximately nine in every ten oil workers in Nigeria have a WMSD. Male gender and work persistence amidst discomfort or pain are the predictors of WMSD among oil workers in Nigeria. Ergonomics training and evaluation programme is recommended for workers in this industry.