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This study shows an improvement in testicular antioxidant activities and sperm qualities by single and double doses of the formulation, suggesting its protective potential against testicular toxicity in diabetic rats.

Background: The therapeutic potentials of the methanolic extract of pineapple peel against alcohol -induced lung injury in male albino rats was investigated. GC -MS was used in characterizing secondary metabolites of the extracts. Methods: Oxidative stress was induced by oral administration of ethanol (20 % w/v) at a dosage of 5 mL/kg body weight in rats. After 28 days of treatment, the rats were fasted overnight and sacrificed by cervical dislocation. Lung tissue homogenates were used for the assessment of protein concentration, reduced glutathione (GSH), catalase, superoxide dismutase (SOD) and lipid peroxidation. Results: GCMS analysis revealed the presence of 10 compounds with ethanimidic acid, ethyl ester (32.52 %) being the most predominant compound. Ingestion of alcohol led to a significant (p < 0.05) reduction in GSH, malondialdehyde (MDA) and protein levels in the lung tissues, this was significantly reversed on treatment with the extract. Ingestion also led to increased significant (p < 0.05) SOD and catalase activity respectively. This was significantly (p < 0.05) reduced on treatment with the extract. Conclusion: These results insinuate the therapeutic potential of the extract against alcoholic oxidative damages in lungs. The identified compounds may influence free radical scavenging and arrest of lipid peroxidation, thereby restoring redox homeostasis.

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