New binuclear Co(II) and Co(II) complexes of ONO tridentate heterocyclic Schiff base derived from 4-aminoantipyrine with salicylaldehyde have been synthesized and characterized on the bases of elemental analysis, UV-Vis., FT-IR, and also by aid of molar conductivity measurements, magnetic measurements, and melting points. It has been found that the Schiff bases with Cu(II) or Co(II) ion forming binuclear complexes on (1 : 1) “metal : ligand” stoichiometry. The molar conductance measurements of the complexes in DMSO correspond to be nonelectrolytic nature for all prepared complexes. Distorted octahedral environment is suggested for metal complexes. A theoretical treatment of the formation of complexes in the gas phase was studied, and this was done by using the HyperChem-6 program for the molecular mechanics and semi-empirical calculations. The free ligand and its complexes have been tested for their antibacterial activities against two types of human pathogenic bacteria: the first type (Staphylococcus aureus) is Gram positive and the second type (Escherichia coli) is Gram negative (by using agar well diffusion method). Finally, it was found that compounds show different activity of inhibition on growth of the bacteria.

Abstract:A new series of Co(II) and Mn(II) complexes with the Flavone ligand were studied on the growth of Rhabdomyo sarcomas (RD) cell Line in human by using in vitro system and compared with anticancer drug cisplatin (cis-pt) as appositive control. The cancer cells were treated with different concentration and cis-pt after 72 hr. exposure time. The cytotoxic activity was tested by inhibition rate as parameter. The results showed significant differences (p<0.05) for each three treatments when the inhibition rates were increased. The synthesized compounds were tested for antimicrobial activity by cup plate diffusion method. The results indicate the enhanced activity of metal complexes over the parent ligands.

Six new macrocyclic complexes were synthesized by template reaction of urea or thiourea with malonic acid and metal (II) chloride. The metal to ligand ratio of the complexes was found to be (1:1). The Co(II) and the Ni(II) complexes are proposed to be square planar and Cu(II) complexes are proposed to be octahedral geometry. Macrocyclic complexes are (1:2) electrolytes for Cu(II) and Ni(II) complexes while Co(II) complexes are non-electrolytic nature as shown by their molar conductivities (Λ M ) in DMSO (Dimethyl sulphoxide) of 10 -3 M solution. The structure of metal complexes from FTIR, UV-Vis., magnetic susceptibility measurements, molar conductivity measurements, atomic absorption and melting points. A theoretical treatment of the formation of complexes in the gas phase was studied, this was done using the HYPERCHEM-6 program for the Molecular mechanics and Semiempirical calculations. The complexes have been tested for their antibacterial activities against Two type of human pathogenic bacteria (Staphylococcus aureus and Escherichia coli). The first are Gram positive while the second are Gram negative (by using agar well diffusion method). Finally, it was found that compounds show different activity of inhibition on growth of the bacteria.

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