Australia/New Zealand (ASR 36.4 and 27.7 per 100,000 for males and females respectively). The incidence of CRC tends to be low in most regions of Western Africa (ASR 7.0 and 5.1 per 100,000 for males and females respectively), and in South Central Asia (ASR 6.2 and 4.0 per 100,000 for males and females respectively) (Sung et al., 2021). In general, the incidence of CRC in high/very high Human Development Index (HDI) countries is higher (ASR 29.0 and 7.4 per 100,000 for males and females respectively) than in the low-and middle HDI countries (ASR 20.0 and 5.4 per 100,000 for males and females respectively) (Sung et al., 2021;Arnold et al., 2020).According to Saudi cancer incidence report in 2018, CRC is the most common cancer among men (15.3%) and third among women (9.8%) (Table 1