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Objective the purpose of this study was to assess the effect grape seeds mouthwash on plaque accumulation in high caries risk individuals. Materials and methods: 66 students were recruited in the study. All students were high caries risk patients. They were divided into three groups according to the protocol they followed for one year. Plaque scores were calculated for each patient at baseline and after one year to show the effect of each preventive protocol. Statistical analysis was done using Chi-Square teat to calculate significance between groups. Result: Chi-Square Test showed that there was no statistical significant difference in the plaque score between the three groups at baseline (p value> 0.05). Regarding the plaque scores at 1-year, Chi-Square Test showed that there was no statistical significant difference between group 1, and group 2. There was a statistical significant difference between group 3 and both groups 1 and 2 at 1-year (p value= 0.000). Conclusion: Grape seeds extract mouthwash can improve the plaque score after 1 year. Natural grape seeds extract is an effective substitute to synthetic agents such as chlorhexidine and fluoride for reducing plaque accumulation.