Aim: Massive methanol poisonings have occurred in the past decades, resulting in a large number of deaths. In this study, our aim is to retrospectively analyze methanol poisoning cases admitted to the emergency department between 2019-2021, to evaluate their demographic characteristics, causes of poisoning, clinical and laboratory findings, treatments applied and mortality, and to contribute to the poisoning data of our country. Material and Method: The cases of methanol poisoning who applied to the emergency department in a 3-year period were analyzed retrospectively. Medical files of patients aged 18 years and older were reviewed. Patients diagnosed with 'methanol poisoning' as a result of the examination were included in the study. Results: A total of 59 patients were included in the study. 88% (n=52) of the patients with a mean age of 53±10 were male. The presence of neurological symptoms and GCS were associated with mortality among the symptoms of patients presenting to the emergency department (p=0.017, p

Background: During the COVID-19 pandemic period, the unnecessary use of the emergency department (ED) affects the motivation of health care providers leading the healthcare services to be far from being efficient, delays the care of the patients having an actual emergency situation and reduces the quality of education in teaching clinics. Methods: Diagnoses in the visits were classified based on International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) categories and were analyzed into subgroups based on common reasons for ED visits. Results: While the number of ED visits in the first year of the pandemic period decreased by 26% compared to the previous year, the frequency of admissions in the circulatory system (CS), stomach and intestinal system (SIS), nervous system (NS), trauma (T), infectious disease (ID), endocrine system (ES), muscular system and connective tissues (MCT), gynecology and pregnancy (GP), environmental emergency (EE), mental and behavioral disorders (MBD), examination and encounter for administrative purposes (EEAP) was higher than expected and the frequency of admission and referral was also significantly more than the expected value (P < 0.001). Conclusion: In addition to the significant decrease in the number of ED visits during the pandemic, the fact that higher admission and referral frequency were observed indicating that the patients visited the emergency service in the late phases with severe clinical conditions. Key Words: COVID-19 pandemic, Emergency Departments, ICD Codes, Patient Admission, Outpatients,

Purpose: Liver damage caused by drugs and other chemicals accounts for about 5% of all cases. Methotrexate (MTX), a folic acid analogue, is a first-line synthetic antimetabolite agent routinely used in the treatment of rheumatoid arthritis and other autoimmune and chronic inflammatory diseases. Polyethylene glycol (PEG) has antioxidant activity. In this study, we evaluated biochemically and histopathologically the antifibrotic effect of PEG 3350 administered intraperitoneally to prevent methotrexate-induced liver damage in rats. Methods: A total of 30 male rats including 10 rats was given no drugs (normal group), and 20 rats received single-dose 20 mg/kg MTX for induced liver injury in this study. MTX was given to 20 rats, which were divided in two groups. Group 1 rats was given PEG 30 mg/kg/day (Merck) intraperitoneally, and Group 2 rats % 0.9 NaCl saline 1 mL/kg/day intraperitoneally daily for two weeks. Results:Transforming growth factor beta (TGF-β), plasma malondialdehyde (MDA), liver MDA, serum tumour necrosis factor alpha (TNF-α), alanine aminotransferase and plasma pentraxin-3 levels and, according to tissue histopathology, hepatocyte necrosis, fibrosis and cellular infiltration were significantly better in MTX+PEG group than in MTX+saline group. Conclusion: PEG 3350 is a hope for toxic hepatitis due to other causes, since liver damage occurs through oxidative stress and cell damage, similar to all toxic drugs.