Distribution of LDH isozymes of human thyroid tissues obtained from patients with hyperthyroidism, adenomatous goiter, non-malignant and malignant tumors was studied by paper (Oxoid) electrophoresis and consequent tétrazolium staining. The shift of the LDH isozyme distribution towards the M type pattern was greatest in cancer (adenocarcinoma) and less in hyperthyroidism and follicular adenoma. The normal thyroid tissue pattern was not symmetrical, but slightly shifted towards the H type. The hyperthyroid and adenomatous goiter tissues showed typical symmetrical patterns, and papillary adenoma tissues exhibited a shift towards the H type distribution.

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