Objective: The aim of the present study was to investigate the role of inflammation in angiogenesis of keratocystic odontogenic tumor (KCOT). Study Design: Twenty inflamed and 20 non-inflamed KCOTs were selected based on quantitative scoring of inflammation which was also applied on 20 radicular cysts. Microvessel density was assessed in all samples using CD34 antibody and angiogenesis was compared between the three groups. Statistical analysis was performed using one-way analysis of variance followed by post-hoc Scheffe test and P values less than 0.05 were considered significant. Results: A statistically significant difference in angiogenesis was found between radicular cysts and both inflamed and non-inflamed KCOTs (P < 0.001), but not between inflamed and non-inflamed KCOTs (P =0.347). Conclusion: Based on the results obtained in the present study, it seems that the effect of inflammation on angiogenesis in KCOT is minimal. However further investigation using other methods of evaluation is suggested to fully clarify the role of “inflammatory angiogenesis” in this neoplasm. Key words:Keratocystic odontogenic tumor, radicular cyst, angiogenesis, inflammation.

Objectives: To determine the occurrence of Activated Leukocyte Cell Adhesion Molecule (ALCAM) and its predictive factors in patients with oral squamous cell carcinoma (OSCC). Methods: This cross sectional study was concocted on 102 patients with OSCC referred to Imam Khomeini Hospital of Tehran during 1997-2015. The data collection tool a checklist consisted of demographic and pathologic (lymph node involvement, differentiation, tumor size and tumor location) characteristics which extracted from patients' medical records. To evaluate ALCAM, a new sample of tumor tissue was prepared from archive. Finally, the multivariable logistic regression model was used to determine the predictive factors of ALCAM by STATA14. Results: the number (%) of men and women were 70 (68.6) and 32 (31.4%), respectively. The mean age (S.D) of participants was 61.7 (15.6) years. Of the total samples, 32 (38.2), 19 (18.6), 36 (35.3) and 8 (7.8%) samples were related to the tongue, oral mucosa, skin and lips, respectively. More than half of the tumors had good differentiation and lymph node involvement and 74.5% were ≥20 mm. Also, 79.41% of the samples were positive for the overall incidence of ALCAM. The most important predictors of the overall

Background: The aim of this study was to evaluate the histopathological findings of oral lesions in patients referred to the pathology department of Kosar Hospital of Semnan city (Iran) in 2012-2018. Materials and Methods: This population-based cross-sectional study was concocted on the histopathological findings of oral lesions 137 patients referred to the pathology department of Kosar Hospital of Semnan city (Iran) in 2012-2018. The sampling method was census. The data collection tool was a check including demographics and dentistry (type of dental lesion, location of the lesion, malignancy of lesions, origin of dental lesions, side of the lesion conflict, jaw involved, anterior-posterior position and type of biopsy). SPSS24 was used for data analysis and a signifi- cance level of less than 0.05 was considered. Results: The most common type and the most common location of oral lesions were periapical cyst (16.7%) and periapical (28.3%); respectively. The most common sources of oral lesions were related to inflammation and connective tissue with 27.5 and 26.8%, respectively. Mandible (47.8%) was the most common involved jaw and 5.1% of reported lesions were malignant. In addition, the prevalence of periapical cyst (78.3 vs. 21.7%) and pyogenic granuloma (82.4 vs. 17.6%) were significantly higher in women than men (P-Value=0.035).The highest rates of periapical cyst (43.5%) and pyogenic granuloma (58.5%) were observed in the age group ≤30 and 31-40 years; respectively (P-Value=0.013). Conclusion: This study suggests that the female patients and over 40 years should be more careful to check for periapical cyst. However, more detailed studies with higher sample sizes are recommended.

Background:Dentistry is considered a difficult occupation. Hence, it could adversely influence the general health and life quality of dentists. Thus, the aim of this study was to evaluate the health-related quality of life (HR-QoL) and its relationship with gender, age, education level, systemic diseases, and job satisfaction among dentists in Semnan in 2015-2016. Methods: This cross-sectional study was conducted among dentists (61 general dentists and 15 dental specialists) in Semnan, Iran, in 2015 -2016. A checklist was used to collect information including gender, age, education level, systemic diseases, and job satisfaction. The HR-QoL was determined by the SF-36 questionnaire. Data were analyzed using SPSS 17 and t-test (P < 0.05).Results: Seventy-six dentists including 40 males (52.6%) and 36 females (47.4%) aged 26-69 years with a mean age of 41.5 ± 7.8 participated in the study. The dentists' HR-QoL was at an appropriate level (total score: 73.2 ± 10.8, physical component: 76.6 ± 12.8, mental component: 64.8 ± 16.0). Gender (males vs. females; P = 0.991), age ( < 35 vs. > 35 years; P = 0.892), education level (general dentists vs. dental specialists; P = 0.590), systemic diseases (with vs. without a systemic disease; P = 0.140), and job satisfaction (satisfied vs. unsatisfied; P = 0.199) revealed no significant effect on the HR-QoL. Conclusions: This study concluded that the dentists working in Semnan had an approximately high level of health-related quality of life.