Background: Globally, Human Immunodeficiency Virus, and malaria co-infection are responsible for high rates of disease and death predominantly in sub-Saharan Africa. However, the relationship between the socio-economic determinants of the human immunodeficiency virus and malaria co-infection has not been established. Therefore, this study aims to determine the socio-economic variables associated with human immunodeficiency virus and malaria co-infection among adults in peri-urban secondary hospitals in the North Central Zone, Nigeria. Method: A retrospective descriptive cross-sectional study was carried out among human immunodeficiency virus-positive patients at six selected peri-urban secondary hospital facilities in the North Central Zone, Nigeria. Continuos variable was compared using the student t-test, or Wilcoxon test, while the categorical variable was compared using Chi-square and Fisher’s exact test. The significance level was kept at p ≤  0.05. Results: This study showed that patients of 61 years and above, those between 18 and 30 years of age are at risk of HIV/malaria co-infection RR 1.09 (0.92 - 1.31) and (95% CI), 1.02 (0.96 - 1.08). A significant relationship was reported between the likelihood of co-infection and education (p = 0.023), residence (p = 0.001), employment, (p < 0.001) and income (p < 0.001). Similarly, the highest proportion of malaria diagnosis 547 (80.9%) was among the un-employed patient’s contrary to the least proportion reported among employed patients 84 (68.3%). Using a logistic regression model, it was noted that the proportion of co-infection among HIV seropositive patients is negatively associated with their income. Conclusion: Findings from this study revealed a strong association between socio-economic variables and HIV/malaria co-infection among the study population. These socio-economic variables could serve as an essential indicator in any proposed intervention programme and could help to predict future co-infection rates in regions where both infectious diseases are dominant.

Background: Human immunodeficiency virus and malaria are significant global health challenges. Both diseases contribute to the global burden of disease and poverty notable amongst low-income countries, including sub-Sahara Africa and Nigeria. There are little or no available review articles on the prevailing epidemiological data on human immunodeficiency virus and malaria interaction in Nigeria. Aim: This literature review aims to update knowledge on human immunodeficiency virus and malaria co-infection and determine the prevalence of human immunodeficiency virus and malaria from published literature. Method: This work reviewed published articles on human immunodeficiency virus/malaria co-infection published in English in PubMed, Google Scholar, and ScienceDirect. An internet search on Google Scholar was also conducted for studies that were conducted between 2007 and 2017 in Nigeria. Result: The literature review indicated that the highest prevalence of human immunodeficiency virus and malaria co-infection in Nigeria is 86.2%. The mean ± SD among the HIV-malaria co-infected group and the negative malaria group in all of Nigeria’s geo-political zones are 36.6 ± 25.5 and 19.5 ± 15.3, respectively. The highest mean prevalence of 64.5% was reported in human immunodeficiency virus patients co-infected with malaria in the northwest zone. The use of highly active antiretroviral therapy is also associated with a reduced mean positive prevalence of 31.26%. Conclusion: Human immunodeficiency virus-positive individuals across all the geopolitical zones in Nigeria are at high risk of malaria. Findings from this review of literature will provide additional information on HIV-malaria co-infection prevalence and guide public health prevention, control and management practice.

Background: Despite a notable reduction in the incidence and prevalence of HIV and malaria, both diseases remain the leading cause of morbidity and mortality, especially in sub-Saharan Africa. The aim of the research study is to provide epidemiological data of malaria among HIV positive individuals, establish the socio-economic determinants associated with HIV-malaria co-infection, and develop a co-infection intervention model. This research study will enable health policymakers to develop new health policies in the management and care of HIV-malaria co-infected patients. Methods and Analysis: The study design will be a retrospective, descriptive cross-sectional study. Case files of HIV positive individuals receiving care and treatment will be randomly selected at six selected peri-urban secondary hospitals. Interviews will be conducted among HIV positive patients, health managers, and doctors at selected hospitals. A mixed method (quantitative and qualitative) will be adopted in the research study. Proportional allocation will be used to select an estimated 1,652 case files of registered patients to be reviewed across the study location. Statistical Package for Social Sciences version 25.0 will be used for data analysis. The categorical variable will be illustrated as a percentage and compared using Chi-square and Fisher’s exact test. Backward multivariate analysis will be used to evaluate HIV-malaria co-infection and associated health outcomes. The continuous variables will be summarised as mean, ± SD or median, interquartile range, and compared using student t-test or Wilcoxon test. Values of P < 0.05 will be considered significant. Qualitative data will be analysed using NVivo 12 software. Strengths and Limitations of This Study Strengths The proposed large sample size of case files to be reviewed will enhance the validity and precision of the research study. Limitations Data that will be generated might not be adequate to make a generalized conclusion for the whole country.    Q= Quarter. Since the study involves the use of secondary data (generated from patient case files), missing data is anticipated.   Strike actions by health care workers were also expected. Another limitation is that the research study will not be conducted as a prospective cohort study. Ethics and Dissemination Considering the research study involves the use of secondary data, the ethical approval issued to conduct the study covers the informed consent of the participants’ information. Copies of written informed consent, participant consent, and confidentiality forms will be provided to the participants both in English and in the native language, notably Hausa, TIV, and Yoruba. Verbal informed and signed informed consent to take part in the study will be obtained from the participants. This study was approved by the University of KwaZulu-Natal Biomedical Research Ethics Committee (BREC)-Reference Number: (BE654/17). Ethical approval was also obtained from the Kwara State Ministry of Health (MOH/KS/EU/777/225), Benue State Ministry of Health (MOH/STA/204/56), and the Nasarawa State Ministry of Health: NHREC 18/06/2017). Findings from this study will be published in peer-reviewed local and international journals. Findings will also be made available to health policymakers at the state ministry of health and hospital facilities selected for the study. The principal investigators and the health providers will sensitize patients on the study outcome.