The lymphoid hematopoietic lineage gives rise to a broad spectrum of immune cell types, including T cells, B cells, and natural killer (NK) cells as a subtype of innate lymphoid cells (ILCs). These cell types are thought to arise from long-term hematopoietic stem cells (HSCs) that reside in the adult bone marrow (BM), later maturing in primary lymphoid organs, namely the thymus and the BM. Following lymphoid commitment, hematopoietic progenitors differentiate to functional T and B cells through a process that incorporates DNA recombination events that generate antigen-specific receptors. In this context, a hallmark of adaptive immune cell development is the expression of the RAG genes (RAG1 and RAG2), encoding proteins that mediate

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