Abstract:Study was carried out in the Fisheries Research Laboratory, Ahmadu Bello University to evaluate the effect of Citrullus colocynthis (Eguisi) and Citrullus vulgaris (Watermelon) seed oils on the larvae of Dermestes maculatus, an important pest of smoke-dried Clarias gariepinus (African catfish). The effect of the oils at different tested concentrations against the larvae of D. maculatus was dose dependent as 3.33% and 81.11% mortality for C. colocynthis while 2.22% and 91.11% for C. vulgaris were recorded for 0.027 mLg of both C. colocynthis and C. vulgaris seed oil could be applied as botanical insecticides to prevent smokedried fish from D. maculatus larvae attack.