Background:The double-capped 26S proteasome complex is viewed as a symmetrical particle. Results: The ubiquitin receptor subunit Rpn13 is found in an asymmetrical ratio. Conclusion: Rpn13 ubiquitin receptor may dictate preference in substrate recruitment and processing. Significance: The ubiquitin receptor Rpn13 defines asymmetry and thus imposes directionality in the 26S proteasome.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.