This study has the purpose to evaluate the effect of an ointment made from the ethanolic extract of S. tuberosum L. var. "Tumbay yellow potato" on skin induced wounds of Mus musculus Balb/c. MATERIALS AND METHODS Biological material Mus musculus Balb/c (30-35 g) males, 12-14 weeks old, obtained from the Instituto Nacional de Salud (INS), were used for this investigation. All mice were kept in individual cages and standard photoperiod environmental conditions (12:12 dark: light cycle) ABSTRACT Background: Solanum tuberosum L. is an Andean tuber that is mainly characterized by its antioxidant properties. Objective: To evaluate the healing activity of an S. tuberosum-based ointment on wounds induced in mice. Material and methods: Ethanolic extracts of peel and pulp of tubers of S. tuberosum "Tumbay yellow potato" were prepared, which were incorporated into 1% and 2% ointment formulations. Mus musculus Balb/c with induced wound were distributed in the following working groups: Group I (Negative Control), Group II (Positive Control: Neomycin, Polymyxin B and Bacitracin Ointment) and Groups III and IV (Ointment at 1 % and 2% of S. tuberosum extract, respectively), daily administration of topical treatments were carried out for 07 days. Wound closure was determined during the experimentation time, then euthanized with sodium pentobarbital 60 mg/kg b.w. (i.p.) to obtain skin samples for histopathological analysis. Results: Groups III and IV showed that better evidence of wound closure and scarring in the histopathological analysis, the greatest effect being in Group IV. Conclusions: S. tuberosum ointments show healing activity in induced wounds in mice, the most effective treatment being the 2% ointment formulation.

La presente investigación buscó determinar el efecto antioxidante de llantén (Plantago major) en conejos sometidos a hipotermia profunda y reperfusión. Para ello, se emplearon 15 conejos, en tres grupos: el primero; mantenido en normotermia; el segundo, llevado a Hipotermia, y el tercero, inducido a Hipotermia/Reperfusión. Al segundo y tercer grupo, se les administró una dosis diaria de 200 mg/Kg de peso corporal de extracto hidroalcohólico de “llantén” por una semana antes de ser inducidos a hipotermia e hipotermia/reperfusión respectivamente. Cabe destacar que a los tres grupos, se les extrajo muestras de sangre al inicio de la investigación, a las dos horas y tres horas, a fin de determinar radicales libres (malondialdehído: MDA) y la actividad del superóxido dismutasa (SOD). El primer grupo, alcanzó la mayor concentración de radicales libres, con un valor promedio de 275,2 µg de MDA.mL-1 plasma (p < 0,05); siendo la actividad de SOD mayor en los grupos tratados con “llantén”, no existiendo diferencia entre los grupos (p > 0,05). Se concluye que la acción antioxidante de llantén (Plantago major), sobre conejos (Oryctolagus cuniculus), se vio potenciada principalmente, bajo condiciones de hipotermia.

El extracto hidroalcohólico de Plantago major "llantén" incrementa la actividad de Catalasa en Oryctolagus cuniculus "conejos" The hydroalcoholic extract of Plantago major "llantén" increases the Catalase activity in Oryctolagus cuniculus "rabbits"

Objective: Determine the content of total phenols and evaluate the gastroprotective effect of the extract of Persea caerulea (Ruiz & Pav.) Mez. in mice with induced gastric ulcer. Material and Methods: The bark of Persea caerulea was macerated in 70% ethanol and the phenol content was determined using the Folin-Ciocalteu method. The female Mus musculus Balb/c specimens were distributed in the following groups: White Control Group, without indomethacin dosing; Negative Control Group, dosing with indomethacin; Positive Control Group treated with ranitidine at a dose of 50 mg/kg; Groups P. caerulea treated with extract at doses of 50 mg/kg, 100 mg/kg and 200 mg/kg. Gastric ulcer was induced with indomethacin orally at a dose of 50 mg/kg, the procedure was repeated 12 hours later; Gastroprotective treatment was administered 60 minutes after each dose of indomethacin, 6 hours after the last dose, sodium pentobarbital was euthanized and the stomach was resected to determine ulceration using the Marhuenda Scale. Results: Higher percentages of gastric ulcer inhibition were obtained in the P. caerulea 100 mg/kg (80%) and P. caerulea 200 mg/kg (85.71%) groups. Conclusions: Extract of Persea caerulea (Ruiz & Pav.) Mez., At doses of 100 and 200 mg/kg of body weight, has a gastric antiulcerative effect which is related to its content of total polyphenols.