MethodsThis study was an analytical research design to assess the NLR as a prognostic factor in HNSCC patients. The inclusion criteria were early and late stage of HNSCC patients with histopathology result was SCC and had never AMJ. 2019;6(4):176-80 Abstract Background: Neutrophil to lymphocyte ratio (NLR) is one of the inflammatory markers, associated with malignancies progression and metastasis, including head and neck squamous cell carcinoma (HNSCC). Neutrophil to lymphocyte ratio is presenting the activity index of protumor and antitumor. It is easy to perform in daily clinical practice, obtained from blood examination. The aim of this study was to assess the prognostic value of NLR in HNSCC patients, associated with the clinical staging. Methods: This study was an analytic design to explore the relationship between NLR and clinical staging. The sample was collected from pre-treatment HNSCC patients who came to the Head and Neck Oncology Clinic, Dr. Hasan Sadikin General Hospital. The data consisted of disease history, ENT examination, staging determination, and blood sample examination for NLR count. Results: In total, data on 92 HNSCC patients were collected. There was a statistically significant association between NLR with clinical staging in HNSCC (p<0.001). The higher the NLR, the higher the clinical stage, whereas the lower the NLR, (OR14.1; 95% CI 3.4-59.0). Conclusions: There is a significant association between NLR with clinical staging in HNSCC. Further study is needed to explore NLR as a prognostic marker in HNSCC patients

Prevalensi penyakit alergi semakin meningkat di seluruh dunia, tetapi hubungan dan pengaruhnya dengan penyakit tiroid autoimun khususnya hipertiroidisme masih belum banyak dibahas dan dimunculkan kasusnya. Kasus ini diajukan untuk memberikan gambaran bahwa rinosinusitis alergi dan penyakit tiroid autoimun khususnya hipertiroidisme memiliki satu mata rantai yang saling berhubungan dari segi patofisiologi dan akan menentukan morbiditas hipertiroidisme tersebut. Dilaporkan dua kasus rinosinusitis alergi disertai hipertiroidisme. Kasus pertama wanita usia 64 tahun dengan benjolan di leher anterior, dan kasus kedua pasien pria usia 61 tahun yang dikonsulkan dari Poliklinik Endokrinologi Penyakit Dalam dengan keluhan utama hidung tersumbat. Pada kedua pasien dilakukan pemeriksaan skor total gejala hidung, penilaian kualitas hidup dengan SNOT-22, pemeriksaan nasoendoskopi dan Tes Kulit Tusuk (TKT), serta pemantauan kadar hormon tiroid dan konsumsi obat antitiroid, kemudian dilakukan tata laksana rinosinusitis alergi dengan pemberian cuci hidung, antibiotik, kortikosteroid intranasal, dan antihistamin generasi kedua. Didapatkan hasil penurunan skor total gejala hidung, perbaikan kualitas hidup, perbaikan secara nasoendoskopi, penurunan kadar hormon tiroid, serta penurunan konsumsi obat antitiroid. Rinosinusitis alergi pada hipertiroidisme harus ditangani dengan baik karena dengan mengatasi rinosinusitis alergi maka akan menurunkan morbiditas hipertiroidisme.Kata kunci: rinosinusitis alergi, penyakit tiroid autoimun, hipertiroidisme