Aim: The study was to fabricate FA nanopowder/Co-Cr-Mo dental alloy nanocomposite using pulsed laser deposition (PLD), and to evaluate bioactivity properties on simulated body fluid. Methods: In this work, the FA nanopowder was prepared by mixing calcium hydroxide (Ca(OH) 2 ), phosphorouspent oxide (P 2 O 5 ) and calcium fluoride (CaF 2 ) in a planetary high energy ball mill using zirconium vial. Fluorapatite (FA) nanopowder was processed in the form of pellet for pulsed laser deposition process. The Co-Cr-Mo alloy was coated with FA nanopowder which was approximately 35 -65 nm at various laser energy, pressure and time. The X-ray diffraction (XRD) was used to analyze phase, crystallinity and size distribution of Co-Cr-Mo/FA nanocomposite. The surface analysis was by scanning electron microscopy (SEM), Atomic Force microscopy (AFM) and Energy dispersive spectroscopy (EDS). Results: From the results obtained, It was shown that FA nanopowder deposited on Co-CrMo alloy was stable during 14 days of incubation on simulated body fluid. It was also observed that the FA nanopowder coated on the surface of the alloy was still intact after the deposition process, which indicated the bioactivity and biocompatibility of the material. Conclusions: The fabrication of FA nanocomposite based dental alloys (Co-Cr-Mo) using PLD was done successfully. This was confirmed by various characterization techniques, which included XRD, AFM, SEM and EDS.